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Advances in anti-fibrosis at the molecular level based on hepatic stellate cells
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 17
- DOI:
- 10.3969/j.issn.1009-3079.2009.17.009
- Key Word:
- 肝星状细胞;细胞外基质;细胞因子;分子机制;Hepatic stellate cells;Extra cellular matrix;Cytokines;Molecular mechanisms
Abstract： Extra cellular matrix (ECM),which plays a key role in the formation of liver fibrosis,mainly comes from the hepatic stellate cells (HSCs). The major components of ECM,includes collagens,glycoproteins,polysaccharides,etc. HSCs can in-fluence or accelarate the process of liver fibrosis through secretion of many cytokines. Recently,many scientists home and abroad focus on HSCs apoptosis and degradation of collagen as a target,in order to find a breakthrough for the prevention and treatment of liver fibrosis.
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