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Advances in anti-fibrosis at the molecular level based on hepatic stellate cells

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Author:
No author available
Journal Title:
WORLD CHINESE JOURNAL OF DIGESTOLOGY
Issue:
17
DOI:
10.3969/j.issn.1009-3079.2009.17.009
Key Word:
肝星状细胞;细胞外基质;细胞因子;分子机制;Hepatic stellate cells;Extra cellular matrix;Cytokines;Molecular mechanisms

Abstract´╝Ü Extra cellular matrix (ECM),which plays a key role in the formation of liver fibrosis,mainly comes from the hepatic stellate cells (HSCs). The major components of ECM,includes collagens,glycoproteins,polysaccharides,etc. HSCs can in-fluence or accelarate the process of liver fibrosis through secretion of many cytokines. Recently,many scientists home and abroad focus on HSCs apoptosis and degradation of collagen as a target,in order to find a breakthrough for the prevention and treatment of liver fibrosis.

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