You Position: Home > Paper
Fecal calprotectin in differential diagnosis between irritable bowel syndrome and inflammatory bowel disease
( views:418, downloads:255 )
- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 11
- DOI:
- 10.3969/j.issn.1009-3079.2009.11.019
- Key Word:
- 炎症性肠病;肠易激综合征;钙卫蛋白;诊断
Abstract： 目的:研究粪钙卫蛋白在炎症性肠病(inflammatory bowel disease,IBD)与肠易激综合征(irritable bowel syndrome,IBS)鉴别诊断中的意义.方法:收集中国人民解放军北京军区总医院消化内镜中心接受肠镜检查患者的新鲜粪便标本共92例,其中溃疡性结肠炎(UC)23例、克罗恩病(CD)4例、IBS 55例、健康人20例.采用ELISA法半定量检测粪便中钙卫蛋白浓度.结果:健康人粪钙卫蛋白浓度为77.15±160.9μg/g,IBS患者为46.08±131.97 μg/g,IBD患者为851.34±522.19 μg/g.IBS患者和健康人粪钙卫蛋白浓度差异无显著差异(P>0.05); IBD与IBS和健康人粪钙卫蛋白水平有显著差异(P<0.001).以60 μg/g为临界值时鉴别IBD与IBS的敏感性86.7%,特异性为96.3%.结论:粪便钙卫蛋白含量检测作为一种非侵入性筛选试验,为临床鉴别IBD和IBS提供了手段.
- [1]刘雁冰,刘菲,袁耀宗.肠道炎症与肠易激综合征[J].2004,(6).
- [2]刘新光.肠易激综合征与罗马Ⅲ诊断标准[J].2006,(12).
- [3]中华医学会消化病学分会炎症性肠病协作组.中国炎症性肠病诊断治疗规范的共识意见[J].2008,(1).
- [4]陈卫中,潘晓平,宋兴勃,等.ROC曲线中最佳工作点的选择[J].2006,(2).
- [5]J Rugtveit,P Brandtzaeg,T S Halstensen,etc.Increased macrophage subset in inflammatory bowel disease: apparent recruitment from peripheral blood monocytes.[J].1994,35(5).
- [6]Gebhardt C,Nemeth J,Angel P,etc.S100A8 and S100A9 in inflammation and cancer.[J].2006,72(11).
- [7]Varoli G,D'Arienzo A,Balzano A,etc.Topical treatment of distal active ulcerative colitis with beclomethasone dipropionate or mesalamine: a single-blind randomized controlled trial.[J].2005,39(4).