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Meta-analysis on the efficacy of lactoferrin supplementation combined with standard treatment during Helicobacter pylori eradication therapy
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 9
- DOI:
- 10.3969/j.issn.1009-3079.2009.09.015
- Key Word:
- 乳铁蛋白;幽门螺杆菌;Meta分析;根除率;不良反应
Abstract： 目的:系统性评价乳铁蛋白联合标准疗法对H pylori根除率的影响,及根除过程中的不良反应发生率.方法:从常用电子数据库检索标准三联或四联疗法联合与未联合乳铁蛋白根除H pylori的随机临床试验,荟萃分析各项研究的根除率和不良反应发生率的合并OR值:进行亚组分析和敏感性分析;以漏斗图检测发表偏倚.结果:共9项随机临床试验(1343例)符合纳入标准.标准疗法联合与未联合乳铁蛋白按意向治疗(ITT)分析的H pylori的根除率分别为86.57%(95%CI:83.99%-89.15%)和74.44%(95%CI:71.14%-77.74%),合并OR值为2.26(95%CI:1.70-3.00);总不良反应发生率分别为9.05%(95%CI:6.83%-11.27%)和16.28%(95%CI:13.43%-19.13%),合并OR值0.15(95%CI:0.04-0.54).结论:联合乳铁蛋白可有效提高标准疗法的H pylori根除率,降低根除过程中的不良反应发生率.
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