Paper - WANFANG MED ONLINE

You Position: Home > Paper

Advance in relationship between COX-2 and gastric cancer

( views:0, downloads:0 )

Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 4

DOI:: 10.3969/j.issn.1009-3079.2009.04.008

Key Word:: 环氧合酶-2;胃癌;环氧合酶

Abstract：环氧合酶2是诱导性酶,在胃癌组织中高表达.主要参与胃癌的血管形成、诱导基因突变、抑制肿瘤免疫、抑制凋亡、改变黏附因子活性,促使肿瘤转移等,对胃癌的发生、发展、预后均起重要的作用.选择性环氧合酶抑制剂具有抑癌作用,有望成为胃癌治疗的基础药物之一.

Reference

[1]张梅,王立东,王俊宽,等.贲门癌癌组织中环氧合酶-2蛋白的表达[J].2007,(3).
[2]朱惠明,王立生,黄勋,等.大肠癌核因子-κB和环氧合酶2的表达及其与肿瘤血管形成的关系[J].2004,(6).
[3]蔡凤林,周士福,马兆生,等.乳腺浸润性导管癌中COX-2、MMP-2的表达及其相关性[J].2008,(1).
[4]Jun Yu,Bao-Dong Tang,Wai K. Leung,etc.Different cell kinetic changes in rat stomach cancer after treatment with celecoxib or indomethacin: Implications on chemoprevention[J].2005,(1).
[5]许小飞,曹兴建,刘雅洁,等.环氧合酶-2在食管癌中表达及与血管生成关系[J].2007,(2).
[6]林瑞新,任辉,张研,等.Hp阳性胃癌患者PG及胃泌素水平的研究[J].2007,(9).
[7]唐爱萍,曲春雁,曲延刚.核因子-κB和环氧合酶-2在胃癌及癌前病变中的表达[J].2007,(13).
[8]石巍,姚育红,廖爱军,等.不同胃黏膜病变中幽门螺杆菌感染与环氧合酶表达相关性分析[J].2004,(12).
[9]李百文,沈强.胃癌组织中环氧合酶-2与基质金属蛋白酶的表达及与胃癌生物学特征的关系[J].2007,(2).
[10]Xiao-Li Chen,Bao-Shan Su,Run-Qin Sun,etc.Relationship between expression and distribution of cyclooxygenase-2 and bcl-2 in human gastric adenocarcinoma[J].2005,(8).
[11]亓玉琴,司君利,魏涛,等.选择性环氧合酶-2抑制剂塞来昔布对胃癌治疗作用的体内实验研究[J].2006,(5).
[12]谭明旗,张秀娟,周卓.Survivin、COX-2蛋白在肺腺癌中的表达及意义[J].2007,(23).
[13]Xiao-Qing Jia,NING Zhong,Li-hui HAN,etc.Effect of NS-398 on colon cancer cells[J].2005,(3).
[14]盛传伦,孙步彤.NSAIDs对胃癌移植瘤的抑制作用及对COX-2、VEGF、NF-KB表达的影响[J].2006,(6).
[15]孙晓杰,黄常志.PI3K-Akt信号通路与肿瘤[J].2006,(3).
[16]朱风尚,陈锡美,王毅军,等.罗非昔布对胃癌细胞BGC-823内在耐药的逆转作用[J].2007,(4).
[17]王海滨,郝素珍,刘蕾,等.幽门螺杆菌对Balb/c小鼠胃粘膜上皮细胞表达环氧合酶-2的影响[J].2007,(5).
[18]Jian-Ying Li,Xiao-Zhong Wang,Feng-Lin Chen,etc.Nimesulide inhibits proliferation via induction of apoptosis and cell cycle arrest in human gastric adenocarcinoma cell line[J].2003,(5).
[19]Xiao-Yun Mao,Xiao-ge WANG,Xiao-Jun Lv,etc.COX-2 expression in gastric cancer and its relationship with angiogenesis using tissue microarray[J].2007,(25).
[20]聂海祺,孙黎光,叶丽平.bFGF经Akt信号转导通路诱导胃癌BGC-823中COX-2和NF-κB表达研究[J].2007,(2).
[21]赵滢,张天彪,王强.胃癌组织caspase-3,Bcl-XL和Cox-2表达与临床病理行为的关系[J].2005,(6).
[22]Farooq M,Haq I,Qureshi AS.Cardiovascular risks of COX inhibition: current perspectives.[J].2008,9(8).
[23]Guo S,Su Y,Gu P,etc.Over-expression of COX-2 induces human ovarian cancer cells (CAOV-3) viability, migration and proliferation in association with PI3-k/Akt activation.[J].2008,26(8).
[24]Brian Gardner,Ling Zhang,Jeff Lin,etc.Cyclooxygenase 2 Inhibition Promotes IFN-gamma-Dependent Enhancement of Antitumor Responses[J].2005,175(2).
[25]Hwang DH,Han JA,Ballou LR,etc.P53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosis.[J].2002,21(21).
[26]Fujiwara K,Kimura T,Senzaki M,etc.CS-706, a novel cyclooxygenase-2 selective inhibitor, prolonged the survival of tumor-bearing mice when treated alone or in combination with anti-tumor chemotherapeutic agents.[J].2008,122(6).
[27]Kobayashi M,Hayashi I,Kitasato H,etc.Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth.[J].2003,197(2).
[28]Grosser T.The pharmacology of selective inhibition of COX-2.[J].2006,96(4).
[29]Jain S,Raja R,Kundu GC,etc.Prostaglandin E2 regulates tumor angiogenesis in prostate cancer.[J].2008,68(19).
[30]Fukuhara K,Fujii S,Takakura K,etc.Increased cyclooxygenase-2 expression is correlated with suppressed antitumor immunity in cervical adenocarcinomas.[J].2006,16(2).
[31]Enders GA.Cyclooxygenase-2 overexpression abrogates the antiproliferative effects of TGF-beta.[J].2007,97(10).
[32]Subramaniam D,Ramalingam S,May R,etc.Gastrin-mediated interleukin-8 and cyclooxygenase-2 gene expression: differential transcriptional and posttranscriptional mechanisms.[J].2008,134(4).
[33]Hiratsuka T,Shindo T,Futagami S,etc.Monocyte chemoattractant protein 1 and CD40 ligation have a synergistic effect on vascular endothelial growth factor production through cyclooxygenase 2 upregulation in gastric cancer.[J].2008,43(3).
[34]Trna J,Dite P,Nenutil R,etc.Expression of COX-2 is associated with accumulation of p53 in pancreatic cancer: analysis of COX-2 and p53 expression in premalignant and malignant ductal pancreatic lesions.[J].2008,20(8).
[35]Huang Y,Sheikh MS,Reddy EP,etc.Celecoxib and a novel COX-2 inhibitor ON09310 upregulate death receptor 5 expression via GADD153/CHOP.[J].2008,27(18).
[36]Russo P,Catassi A,Paleari L,etc.Nicotine, lung and cancer.[J].2007,7(4).
[37]Appleby S B,Ristim\u00e4ki A,Neilson K,etc.Structure of the human cyclo-oxygenase-2 gene[J].1994.
[38]P C, Konturek,S J, Konturek,T, Brzozowski.Gastric cancer and Helicobacter pylori infection.[J].2006,57 Suppl 3.
[39]Luo T,Zhang MM,Qian K,etc.Expression of cyclooxygenase-2 and vascular endothelial growth factor-C correlates with lymphangiogenesis and lymphatic invasion in human gastric cancer.[J].2008,39(1).
[40]Rehab M, Samaka,Asmaa G, Abdou,Moshira M, Abd El-Wahed,etc.Cyclooxygenase-2 expression in chronic gastritis and gastric carcinoma, correlation with prognostic parameters.[J].2006,18(4).
[41]Randall E, Harris,Joanne, Beebe-Donk,Galal A, Alshafie.Similar reductions in the risk of human colon cancer by selective and nonselective cyclooxygenase-2 (COX-2) inhibitors.[J].2008,8.
[42]Rao DS,Gui D,Koski ME,etc.An inverse relation between COX-2 and E-cadherin expression correlates with aggressive histologic features in prostate cancer.[J].2006,14(4).
[43]Pera M,Elizalde JI,Palacin A,etc.Positive VEGF immunostaining independently predicts poor prognosis in curatively resected gastric cancer patients: results of a study assessing a panel of angiogenic markers.[J].2008,12(6).
[44]Mizokami Y,Takahashi K,Matsuzaki Y,etc.The effects of cyclooxygenase2-prostaglandinE2 pathway on Helicobacter pylori-induced urokinase-type plasminogen activator system in the gastric cancer cells[J].2008,13(3).
[45]Zhou S,Zhao Y,Heng CK.Celecoxib inhibits serum amyloid a-induced matrix metalloproteinase-10 expression in human endothelial cells.[J].2009,46(1).
[46]Cheng-Xiong, Xu,Hua, Jin,Youn-Sun, Chung,etc.Chondroitin sulfate extracted from ascidian tunic inhibits phorbol ester-induced expression of Inflammatory factors VCAM-1 and COX-2 by blocking NF-kappaB activation in mouse skin.[J].2008,56(20).