You Position: Home > Paper

Expression of Aurora-B in hepatocarcinoma and its clinical significance

( views:237, downloads:76 )
Author:
No author available
Journal Title:
WORLD CHINESE JOURNAL OF DIGESTOLOGY
Issue:
3
DOI:
10.3969/j.issn.1009-3079.2009.03.008
Key Word:
肝癌;Aurora-B;预后

Abstract´╝Ü 目的: 了解基因Aurora-B在肝癌中的表达及其作为预测肝癌预后的新指标的可能性.方法: 收集2001-2007年我院初治的肝癌患者标本80例, 病理证实均为肝细胞癌. 用免疫组化法检测患者标本中Aurora-B的表达, 分析Aurora-B的表达与肝癌患者年龄、性别、临床分期等的关系及其与预后的关系.结果: Au r o r a-B在肝癌标本中的表达率为68.8%; 临床分期、肿瘤大小、肿瘤合并门静脉癌栓与Au r o r a-B表达阳性率的差异有统计学意义(χ2 = 99.9669, 20.8185, 28.5214,均P<0.05). 80例根治性肝癌切除的病例中,Aurora-B表达与肝细胞癌1, 2年复发率和生存率之间有关(χ2 = 5.7702, 5.4257, 均P<0.05; χ2= 11.8787, 10.4497, 均P<0.05).结论: Aurora-B在肝癌组织中有一定程度表达, 其表达与肝癌临床分期及预后相关.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn