You Position: Home > Paper
Expression of Aurora-B in hepatocarcinoma and its clinical significance
( views:253, downloads:76 )
- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 3
- DOI:
- 10.3969/j.issn.1009-3079.2009.03.008
- Key Word:
- 肝癌;Aurora-B;预后
Abstract： 目的: 了解基因Aurora-B在肝癌中的表达及其作为预测肝癌预后的新指标的可能性.方法: 收集2001-2007年我院初治的肝癌患者标本80例, 病理证实均为肝细胞癌. 用免疫组化法检测患者标本中Aurora-B的表达, 分析Aurora-B的表达与肝癌患者年龄、性别、临床分期等的关系及其与预后的关系.结果: Au r o r a-B在肝癌标本中的表达率为68.8%; 临床分期、肿瘤大小、肿瘤合并门静脉癌栓与Au r o r a-B表达阳性率的差异有统计学意义(χ2 = 99.9669, 20.8185, 28.5214,均P<0.05). 80例根治性肝癌切除的病例中,Aurora-B表达与肝细胞癌1, 2年复发率和生存率之间有关(χ2 = 5.7702, 5.4257, 均P<0.05; χ2= 11.8787, 10.4497, 均P<0.05).结论: Aurora-B在肝癌组织中有一定程度表达, 其表达与肝癌临床分期及预后相关.
- [1]Jed Abraham, Katzel,Amitabha, Mazumder,Sundar, Jagannath,etc.Engraftment syndrome after hematopoietic stem cell transplantation in multiple myeloma.[J].2006,7(2).
- [2]Bian M,Fu J,Zhang C,etc.Roles of Aurora kinases in mitosis and tumorigenesis.[J].2007,5(1).
- [3]Sen S,Katayama H,Brinkley WR.The Aurora kinases: role in cell transformation and tumorigenesis.[J].2003,22(4).
- [4]Andrew, Mortlock,Nicholas J, Keen,Frederic H, Jung,etc.Progress in the development of selective inhibitors of Aurora kinases.[J].2005,5(2).
- [5]Gilberg S,Sengar DP,Lamba WR,etc.Lymphoproliferative lesions of the lacrimal gland: clinicopathological, immunohistochemical and molecular genetic analysis.[J].2005,40(2).
- [6]Naruganahalli KS,Dastidar SG,Ray A,etc.Therapeutic potential of Aurora kinase inhibitors in cancer.[J].2006,7(12).
- [7]Venoux M,Basbous J,Lamb NJ,etc.ASAP is a novel substrate of the oncogenic mitotic kinase Aurora-A: phosphorylation on Ser625 is essential to spindle formation and mitosis.[J].2008,17(2).
- [8]Li JJ,Li SA.Mitotic kinases: the key to duplication, segregation, and cytokinesis errors, chromosomal instability, and oncogenesis.[J].2006,111(3).
- [9]Macarulla T,Ramos FJ,Tabernero J.Aurora kinase family: a new target for anticancer drug.[J].2008,3(2).