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Changes of G and D cells and expression of gastrin and somatostatin in gastric mucosa of chronic superficial gastritis with spleen-stomach dampness-heat syndrome

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Author:
No author available
Journal Title:
WORLD CHINESE JOURNAL OF DIGESTOLOGY
Issue:
34
DOI:
10.3969/j.issn.1009-3079.2008.34.005
Key Word:
慢性浅表性胃炎;脾胃湿热证;G细胞;D细胞;胃泌素;生长抑素

Abstract´╝Ü 目的:探讨慢性浅表性胃炎脾胃湿热证患者胃黏膜G、D细胞的变化及胃泌素和生长抑素表达的意义.方法:2004-05/2005-03北京市东直门医院消化科门诊或住院的慢性浅表性胃炎患者70例,其中脾胃湿热证38例,脾胃虚弱证32例.用免疫组化的方法检测患者胃黏膜中G、D细胞的数目和胃泌素和生长抑素表达的量值.结果:与脾虚组比较,湿热组胃黏膜G细胞数目,D细胞数目,G、D细胞比值,G细胞总面积即Gas表达量,D细胞总面积即SS的表达量有显著性差异(130.54±35.62 vs 111.13±23.79,54.98±19.63 vs 67.01±21.56,2.74±1.36 vs1.87±1.36,34.72±17.24 vs 27.72±14.23,13.90±7.22 vs 19.23±7.96,P<0.05或0.01).结论:G细胞增多,胃黏膜Gas增多,D细胞减少,胃黏膜SS减少,可能是湿热证的病理基础;而D细胞增多,胃黏膜SS分泌亢进,G细胞减少,胃黏膜Gas水平低下,可能是脾虚证的病理基础.

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