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Advance in Helicobacter pylori resistance to clarithromycin

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 27

DOI:: 10.3969/j.issn.1009-3079.2008.27.008

Key Word:: 幽门螺杆菌;耐药性;突变;克拉霉素

Abstract：幽门螺杆(Hpylon)是慢性胃炎,消化性溃疡的重要致病因素.研究表明,H pylori的根治和清除有利于溃疡的治愈.而H pylori耐药直接影响H pylori根治和清除,H pylori耐大环内酯类药物(克拉霉素)的机制与他的23S rRNA的V区上的点突变有关.随着H pylori耐药率的逐年升高,有关H pylori的耐药分子机制和检测技术成为研究热点.因此,开展H pylori耐药的相关研究对H pylori的诊断和治疗有重大意义.

Reference

[1]陈洁,陈飞波,余金丹,等.幽门螺杆菌对克拉霉素、阿莫西林、甲硝唑体外耐药性和敏感性的初步分析[J].2004,(10).
[2]Qing Hao,YAN Li,Zhi-Jie Zhang,etc.New mutation points in 23S rRNA gene associated with Helicobacter Pylori resistance to clarithromycin in northeast China[J].2004,(7).
[3]成虹,胡伏莲.北京地区幽门螺杆菌耐药情况及其变化趋势[J].2005,(39).
[4]郭树彬,刘军波,陈琳洁,等.幽门螺杆菌基因分型及耐药检测寡核苷酸芯片的制备及鉴定[J].2007,(1).
[5]胡伏莲.重视幽门螺杆菌耐药菌株的研究[J].2006,(7).
[6]Toracchio S,Aceto GM,Marzio L,etc.Identification of a novel mutation affecting domain V of the 23S rRNA gene in Helicobacter pylori[J].2004,9(5).
[7]Pace A,Hassan C,Stoppino G,etc.Prevalence of primary clarithromycin resistance in Helicobacter pylori strains over a 15 year period in Italy.[J].2007,59(4).
[8]Kobayashi I,Murakami K,Kato M,etc.Changing antimicrobial susceptibility epidemiology of Helicobacter pylori strains in Japan between 2002 and 2005.[J].2007,45(12).
[9]Owen RJ,Palmer C,Elviss NC,etc.Helicobacter pylori antibiotic-resistance patterns and risk factors in adult dyspeptic patients from ethnically diverse populations in central and south London during 2000.[J].2005,54(6).
[10]Aydin A,Tekin F,Onder G,etc.High Helicobacter pylori resistance rate to clarithromycin in Turkey.[J].2007,41(8).
[11]Maisawa S,Shimizu T,Kato S,etc.Antibiotic resistance of Helicobacter pylori strains in Japanese children.[J].2002,40(2).
[12]Owen RJ,Elviss NC,Lawson AJ.Application of 3 '-mismatched reverse primer PCR compared with real-time PCR and PCR-RFLP for the rapid detection of 23S rDNA mutations associated with clarithromycin resistance in Helicobacter pylori[J].2004,23(4).
[13]Walker AM,Owen RJ,Elviss NC,etc.Helicobacter pylori antibiotic resistance patterns and genotypes in adult dyspeptic patients from a regional population in North Wales.[J].2004,54(2).
[14]Iwanczak F,Grabinska J,Przondo-Mordarska A,etc.High level of resistance to metronidazole and clarithromycin in Helicobacter pylori isolated from pediatric patients in Poland (1997-2001)[J].2004,49(2).
[15]Lazarova E,Koumanova R,Mitov I,etc.Risk factors for primary Helicobacter pylori resistance in Bulgarian children.[J].2004,53(9).
[16]Fontana C,Pietroiusti A,Pistoia ES,etc.Detection of clarithromycin-resistant Helicobacter pylori in stool samples.[J].2003,41(8).
[17]Alarcon T,Lopez Brea-M,Domingo D,etc.PCR using 3'-mismatched primers to detect A2142C mutation in 23S rRNA conferring resistance to clarithromycin in Helicobacter pylori clinical isolates.[J].2000,38(2).
[18]FMe&#769,graud.H pyloriantibiotic resistance: prevalence, importance, and advances in testing[J].2004,53(9).
[19]Sultana J,Nahar S,Khan R,etc.T2182C Mutation in 23S rRNA Is Associated with Clarithromycin Resistance in Helicobacter pylori Isolates Obtained in Bangladesh.[J].2004,48(9).