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Role of hepatocyte apoptosis in non-alcoholic fatty liver disease

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 20

DOI:: 10.3969/j.issn.1009-3079.2008.20.011

Key Word:: 非酒精性脂肪性肝病;非酒精性脂肪性肝炎;细胞凋亡

Abstract：非酒精性脂肪性肝病(non-alcoholic fatty liver disease.NAFLD)是指除外酒精和其他明确的损肝因素所致的,以弥漫性肝细胞大泡性脂肪变为主要特征的临床病理综合征.随着生活水平的提高、生活习惯、饮食结构的改变,肥胖和糖尿病的发病率增加,NAFLD的发病率呈上升趋势,严重危害人民健康.而非酒精性脂肪性肝病的发病机制仍不十分清楚,最近研究表明细胞凋亡及其相关因素Fas系统、TNF家族、Bel-2蛋白家族、Caspases蛋白酶家族、NF-κB、细胞色素C及组织蛋白酶B等在NAFLD中表达异常增多,说明肝细胞凋亡在NAFLD的发生进展中扮演了至关重要角色.本文就这方面的研究进展作一综述.

Reference

[1]姜山,谢青,张(韦华),等.Caspase-12活化在小鼠原代肝细胞凋亡中的作用[J].2006,(1).
[2]Marko Duvnjak,Ivan Leroti(c),Neven Bar(s)i(c),etc.Pathogenesis and management issues for non-alcoholic fatty liver disease[J].2007,(34).
[3]吴涛,季光,郑培永,等.内质网应激与肝细胞凋亡[J].2007,(23).
[4]中华医学会肝脏病学分会脂肪肝和酒精性肝病学组.非酒精性脂肪性肝病诊疗指南[J].2006,(3).
[5]南月敏,胡云龙,付娜,等.Bad、Bax和Bid蛋白表达在非酒精性脂肪性肝炎中的作用[J].2008,(1).
[6]李继强,柳怿,刘文忠,等.依那普利对肝组织bax和bcl-2基因表达的影响[J].2006,(8).
[7]慕永平,刘平,都广礼,等.CCl4诱导大鼠肝硬化形成过程中Caspase-12蛋白表达与肝细胞凋亡的相关性[J].2008,(2).
[8]丁效蕙,赵景民.非酒精性脂肪性肝炎的发病机制及治疗的研究进展[J].2005,(3).
[9]张莉,贾继东,张华,等.己酮可可碱抑制非酒精性脂肪性肝炎TNF-α的实验研究[J].2007,(4).
[10]南月敏,乔梁,于君,等.Fas及其配体诱导非酒精性脂肪性肝炎肝细胞凋亡[J].2006,(12).
[11]崔焱,张莉,贾继东.己酮可可碱对大鼠非酒精性脂肪性肝炎细胞外基质合成与降解的影响[J].2007,(2).
[12]Cubre A,Orenstein J,Bidere N,etc.Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1[J].2006,26(9).
[13]Kerr J F R,Wyllie A H,Currie A R.Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics[J].1972.
[14]Day,CP,James,OF.Steatohepatitis: a tale of two "hits"? (editorial)[J].1998,114(4).
[15]M, Pérez Carreras,G, Castellano Tortajada.[Non-alcoholic fatty liver disease].[J].2005,97(5).
[16]Svegliati-Baroni G,Tiribelli C,Gastaldelli A,etc.Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis.[J].2008,14(2).
[17]Towner RA,Inoue Y,Kotake Y,etc.Modulation of Fas-FasL related apoptosis by PBN in the early phases of choline deficient diet-mediated hepatocarcinogenesis in rats.[J].2007,41(9).
[18]Gores GJ,Baskin Bey ES,Guicciardi ME,etc.Cathepsin B inactivation attenuates hepatocyte apoptosis and liver damage in steatotic livers after cold ischemia-warm reperfusion injury.[J].2005,288(2).
[19]Hughes M,Cohen GM,Harper N,etc.Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis.[J].2003,278(28).
[20]Hatano E.Tumor necrosis factor signaling in hepatocyte apoptosis.[J].2007,22(Suppl.1).
[21]Ong JP,Younossi ZM.Epidemiology and natural history of NAFLD and NASH.[J].2007,11(1).
[22]Gao W,Beg AA,Ding WX,etc.Bid-independent mitochondrial activation in tumor necrosis factor alpha-induced apoptosis and liver injury.[J].2007,27(2).
[23]Ding WX,Yin XM.Death receptor activation-induced hepatocyte apoptosis and liver injury.[J].2003,3(6).
[24]Kanemoto S,Hara H,Saito A,etc.BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer[J].2007,27(5).
[25]Kohlhaas SL,Cohen GM,Craxton A,etc.Receptor-mediated endocytosis is not required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis.[J].2007,282(17).
[26]Canbay A,Taimr P,Friedman S,etc.Apoptotic body engulfment by a human stellate cell line is profibrogenic.[J].2003,83(5).
[27]Berrington WR,Harlan JM,Altemeier WA,etc.Fas (CD95) induces macrophage proinflammatory chemokine production via a MyD88-dependent, caspase-independent pathway.[J].2007,82(3).
[28]Cortez Pinto H,Castro RE,Moura MC,etc.Apoptosis and Bcl-2 expression in the livers of patients with steatohepatitis.[J].2006,18(1).
[29]Liu C,Yan X,Sun M,etc.Inhibition of hepatic stellate cell activation following Yinchenhao decoction administration to dimethylnitrosamine-treated rats.[J].2008,38(9).
[30]Saile B,Ramadori G,Matthes N,etc.The bcl, NF kappa B and p53/p21(WAF1) systems are involved in spontaneous apoptosis and in the anti-apoptotic effect of TGF-beta or TNF-alpha on activated hepatic stellate cells[J].2001,80(8).
[31]Bajt ML,Jaeschke H,Gujral JS.Apoptosis and necrosis in liver disease.[J].2004,24(2).
[32]Jum Ji,Ping Wang,Yi-Ming Mu.Saturated free fatty acid, palmitic acid, induces apoptosis in fetal hepatocytes in culture[J].2005,56(6).
[33]Malhi H,Bronk SF,Gores GJ,etc.Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis.[J].2006,281(17).
[34]J, Ludwig,T R, Viggiano,D B, McGill,etc.Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease.[J].1980,55.
[35]Flavell RA,Porter GA Jr,Mehal WZ,etc.Caspases 3 and 7: key mediators of mitochondrial events of apoptosis.[J].2006,311(5762).
[36]Vadrot N,Fau D,Cazanave S,etc.High hepatic glutathione stores alleviate Fas-induced apoptosis in mice.[J].2007,46(5).
[37]Rey C,Kinnman N,Francoz C,etc.The myofibroblastic conversion of peribiliary fibrogenic cells distinct from hepatic stellate cells is stimulated by platelet-derived growth factor during liver fibrogenesis.[J].2003,83(2).
[38]Casey CA,Lee SM,Aziz Seible R,etc.Impaired receptor-mediated endocytosis: its role in alcohol-induced apoptosis.[J].2008,23(Suppl.1).
[39]Schattenberg JM,Galle PR,Schuchmann M.Apoptosis in liver disease.[J].2006,26(8).
[40]Marcellini M,Manco M,Nobili V,etc.Correlation of serum TNF-alpha levels and histologic liver injury scores in pediatric nonalcoholic fatty liver disease.[J].2007,127(6).
[41]Feldstein AE,Carter-Kent C,Zein NN.Cytokines in the pathogenesis of fatty liver and disease progression to steatohepatitis: implications for treatment.[J].2008,103(4).