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Advances in PTEN and hepatic diseases

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 17

DOI:: 10.3969/j.issn.1009-3079.2008.17.013

Key Word:: PTEN;肝脏疾病;肝细胞癌

Abstract：过去,PTEN在肿瘤发生发展中的作用是研究的热点.近年来,一些学者广泛关注PTEN在某些非肿瘤疾病中的作用.肝脏疾病方面,除对PTEN在肝细胞癌发生发展中的作用进行研究外,也有一些PTEN与其他肝脏疾病关系的研究.本文就PTEN的发现、结构、功能及与肝脏疾病的关系等作一综述.

Reference

[1]Dong-Zhu Ma,Zhen Xu,Yu-Long Liang,etc.Down-regulation of PTEN expression due to loss of promoter activity in human hepatocellular carcinoma cell lines[J].2005,(29).
[2]吴淑坤,王宝菊,杨燕,等.PTEN和磷酸化Smad2在原发性肝癌中的表达[J].2007,(8).
[3]TAO Jing,XIONG Jiongxin,LI Tao,etc.Correlation between Protein Expression of PTEN in Human Pancreatic Cancer and the Proliferation, Infiltration, Metastasis and Prognosis[J].2006,(4).
[4]John J Lah,Wei CUI,Ke-Qin Hu.Effects and mechanisms of silibinin on human hepatoma cell lines[J].2007,(40).
[5]Li-Rong Yin,Ze-Xiong Chen,Shi-Jun Zhang,etc.Expression of phosphatase and tensin homolog deleted on chromosome ten in liver of athymic mice with hepatocellular carcinoma and the effect of Fuzheng Jiedu Decoction[J].2008,(1).
[6]黄爱民,丁毅,刘景丰,等.生存素、p27和PTEN在肝细胞癌中的表达及临床病理意义[J].2008,(1).
[7]Smith WM,Brown JL,Weng LP,etc.PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model.[J].2001,10(6).
[8]Sasaki T,Hamada K,Sasaki J,etc.Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas.[J].2004,113(12).
[9]Im JH,Lee JH,Kang-Park S,etc.PTEN modulates hepatitis B virus-X protein induced survival signaling in Chang liver cells.[J].2006,122(1).
[10]Li, Jing,Yen, Clifford.PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate canc[J].1997,275(5308).
[11]Dixon JE,Das S,Cho W.Membrane-binding and activation mechanism of PTEN.[J].2003,100(13).
[12]Ohshima S,Watanabe S,Kataoka E,etc.Non-alcoholic steatohepatitis and hepatocellular carcinoma: lessons from hepatocyte-specific phosphatase and tensin homolog (PTEN)-deficient mice.[J].2007,22(Suppl.1).
[13]J A, Diehl,M, Cheng,M F, Roussel,etc.Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.[J].1998,12.
[14]Alice, Hlobilková,Jana, Knillová,Jirí, Bártek,etc.The mechanism of action of the tumour suppressor gene PTEN.[J].2003,147(1).
[15]Siddiqui A,Negro F,Felmlee DJ,etc.Hepatitis C virus induces proteolytic cleavage of sterol regulatory element binding proteins and stimulates their phosphorylation via oxidative stress[J].2007,81(15).
[16]Nishisho I,Umeshita K,Gotoh M,etc.PTEN/MMAC1 mutation and frequent loss of heterozygosity identified in chromosome 10q in a subset of hepatocellular carcinomas.[J].2000,91(3).
[17]Tonks NK,Torres J,Graves JD,etc.Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: implications for the control of protein stability and PTEN-protein interactions.[J].2003,278(33).
[18]Diana Murray,Barry Honig.Electrostatic Control of the Membrane Targeting of C2 Domains[J].2002,9(1).
[19]Hill S,Janas ML,Trotman LC,etc.The effect of deleting p110delta on the phenotype and function of PTEN-deficient B cells.[J].2008,180(2).
[20]D M, Li,H, Sun.TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta.[J].1997,57.
[21]Grossman SR,Vazquez F,Rokas MV,etc.Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex.[J].2001,276(52).
[22]Rubbia-Brandt L,Foti M,Veyrat-Durebex C,etc.PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism.[J].2008,134(1).
[23]Stiles B,Lee WP,Kim YJ,etc.Live-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity[J].2004,101(7).
[24]Murai Y,Nomoto K,Takahashi H,etc.Expressions of MMP-2, MMP-9 and VEGF are closely linked to growth, invasion, metastasis and angiogenesis of gastric carcinoma.[J].2006,26(5A).
[25]Selvendiran K,Tong L,Kutala VK,etc.EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression.[J].2007,282(39).
[26]Liu SQ,Jiang M,Cao HF,etc.The alteration of PTEN tumor suppressor expression and its association with the histopathological features of human primary hepatocellular carcinoma.[J].2003,129(2).
[27]Choi HJ,Chung TW,Kang SK,etc.Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway.[J].2006,16(7).
[28]Pulido R,Torres J.The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation.[J].2001,276(2).
[29]Li ZR,Gautam A,Bepler G.RRM1-induced metastasis suppression through PTEN-regulated pathways.[J].2003,22(14).
[30]Park SH,Jung HY,Kang SY,etc.Combination of PTEN and gamma-ionizing radiation enhances cell death and G(2)/M arrest through regulation of AKT activity and p21 induction in non-small-cell lung cancer cells.[J].2008,70(5).
[31]Spits H,Hagenbeek TJ.T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus.[J].2008,22(3).
[32]He JY,Yu Q,Zha XL,etc.Study of the PTEN gene expression and FAK phosphorylation in human hepatocarcinoma tissues and cell lines[J].2004,262(1).
[33]Fujiwara S,Ohnishi T,Kohno S,etc.PTEN gene transfer suppresses the invasive potential of human malignant gliomas by regulating cell invasion-related molecules.[J].2006,29(1).
[34]Wu RC,Schonthal AH,Li X.Transcriptional activation of p21WAF1 by PTEN/MMAC1 tumor suppressor.[J].2000,203(1).
[35]Kalita O,Ehrmann J,Sedlakova E,etc.Could changes in the regulation of the PI3K/PKB/Akt signaling pathway and cell cycle be involved in astrocytic tumor pathogenesis and progression?[J].2007,54(4).
[36]Kim HM.,Moon SK.,Kim CH..PTEN induces G(1) cell cycle arrest and inhibits MMP-9 expression via the regulation of NF-KB and AP-1 in vascular smooth muscle cells[J].2004,421(2).
[37]Antonarakis SE,Valiente M,Torres J,etc.Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases[J].2005,280(32).
[38]Ostrowski MC,Chung JH,Waite KA,etc.The ERK1/2 pathway modulates nuclear PTEN-mediated cell cycle arrest by cyclin D1 transcriptional regulation.[J].2006,15(17).
[39]Harris SJ,Parry RV,Westwick J,etc.Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes.[J].2008,283(5).