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Significance of E-cadherin, β-catenin and CathepsinD expression in esophageal squamous cell carcinoma
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 16
- DOI:
- 10.3969/j.issn.1009-3079.2008.16.009
- Key Word:
- 上皮型钙黏素;β-连环素;组织蛋白酶D;食管鳞状细胞癌;免疫组化
Abstract： 目的: 探讨上皮型钙黏素(E-cadherin)、β-连环素(β-catenin)和组织蛋白酶D(CathepsinD)在食管鳞状细胞癌(ESCC)中的表达及其与临床病理特征的关系.方法:选取新疆医科大学第一附属医院2003-06/2007-07手术切除并经病理证实的ESCC标本60例,同时选取15例正常食管组织作对照.采用免疫组织化学EnVision二步法检测各组织中E-cadherin、β-catenin及CathepsinD的表达,分析其与食管鳞状细胞癌临床病理特征的关系.结果:ESCC组织中,E-cadherin和β-catenin异常表达率分别为61.67%和66.67%,CathepsinD的阳性表达率为60%,分别高于正常食管组织(0%,0%,0%,均P<0.01).中低分化组、侵及肌层组及有淋巴结转移组中,E-cadherin和β-catenin的异常表达和CathepsinD的阳性表达均高于高分化组、未侵及肌层组及无淋巴结转移组,差异有统计学意义(P<0.01).ESCC组织中E-cadherin和β-catenin的异常表达呈正才目关(r=0.679,P<0.01),CathepsinD的阳性表达与E-cadherin、β-catenin的异常表达呈正相关(r=0.616, r=0.505,P<0.01).结论:ESCC中E-cadherin、β-catenin的异常表达和CathepsinD的阳性表达与肿瘤的浸润和发展有关,联合检测E-cadherin、β-catenin和CathepsinD有可能成为判断ESCC恶性程度和预后的重要指标.
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