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Correspondence analysis and simultaneous detection of p53 and MDM2 protein expression in human gastric cancer using tissue microarray
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 11
- DOI:
- 10.3969/j.issn.1009-3079.2008.11.010
- Key Word:
- 胃癌;p53蛋白;MDM2蛋白;对应分析;组织微阵列
Abstract： 目的:探讨胃癌组织中p53和MDM2蛋白表达的相互关系.方法:47例石蜡包埋胃癌组织制成组织阵列,应用免疫组织化学方法检测其p53和MDM2蛋白表达,并运用统计软件SPSS11.5对两个蛋白之间的相互关系进行对应分析.结果:p53与MDM2蛋白阳性表达率分别为34.0%(16/47)和42.5%(20/47).p53蛋白与MDM2蛋白表达呈负相关(P=0.012).结论:p53突变是胃癌发生发展中重要的一步,MDM2可能在胃癌的恶性增生过程中起重要作用.
- [1]薄爱华,张晓丽,邢立强,等.MDM2与p21、p53在胃癌、食管癌中表达的相关性研究[J].2001,(1).
- [2]李灵敏,刘育艳.p53和MDM2在食管鳞癌中的作用及相关性分析[J].2005,(1).
- [3]黄越承,蔡建明.MDM2功能及其调控机制[J].2004,(5).
- [4]孙宝华,武忠弼,阮幼冰,等.肝细胞癌mdm2基因表达及其与p53基因突变的关系[J].1999,(4).
- [5]孙迎娟,时飞,孙坚萍,等.胃癌组织中p53基因突变及p53和mdm2蛋白表达的研究[J].2005,(13).
- [6]孙利平,李岩,张宁,等.MDM2基因扩增和蛋白表达与胃癌相关性的研究[J].2003,(11).
- [7]浣孝强,孟斌,邓卓霖,等.MDM2、p53和p21WAF1/CIP1蛋白在胃癌中的表达及意义[J].2002,(1).
- [8]刘壮,龙桂芳.MDM2、p53基因及其蛋白质与恶性肿瘤[J].2003,(6).
- [9]Chong Lu,Hui-Mian Xu,Qun Ren,etc.Somatic mutation analysis of p53 and ST7 tumor suppressor genes in gastric carcinoma by DHPLC[J].2003,(12).
- [10]D J, Adamson,W D, Thompson,A A, Dawson,etc.P53 Mutation and Expression in Lymphoma.[J].1995,72.
- [11]Hu W,Bond GL,Levine AJ.MDM2 is a central node in the p53 pathway: 12 years and counting.[J].2005,5(1).
- [12]李凤歧,薄爱华.尿路上皮癌mdm-2,p53蛋白及性激素受体免疫化研究[J].2000,015 (1).
- [13]Shuin T,Ohtsuki Y,Akiyama Y,etc.Missense mutation of the hMSH6 and p53 genes in sporadic urothelial transitional cell carcinoma.[J].2000,16(3).
- [14]CHEUNG,SHEN,KHOO,etc.Immunohistochemical and mutational analysis of p53 tumor suppressor gene in gestational trophoblastic disease: correlation with mdm2, proliferation index, and clinicopathologic parameters[J].1999,9(2).
- [15]C, Prives.Signaling to p53: breaking the MDM2-p53 circuit.[J].1998,95(1).
- [16]S, Inoue,E, Tezel,A, Nakao.Molecular diagnosis of pancreatic cancer.[J].1900,48(40).
- [17]Jiang J,Chen X,Zhu J,etc.Definition of the p53 functional domains necessary for inducing apoptosis.[J].2000,275(51).
- [18]Konig C,Wienzek S,Roth J,etc.Inactivation of the p53-homologue p73 by the mdm2-oncoprotein.[J].1999,18(12).
- [19]Lahav G,Rosenfeld N,Sigal A,etc.Dynamics of the p53-Mdm2 feedback loop in individual cells.[J].2004,36(2).
- [20]Itahana K,Zhang Y,Clegg HV.Unlocking the Mdm2-p53 loop: ubiquitin is the key.[J].2008,7(3).
- [21]Yili Yin,M. Gloria Luciani,Robin Fahraeus.p53 stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products[J].2002,4(6).
- [22]Walker MM,Robinson PA,Jeremy AH,etc.Long-term infection with Helicobacter felis and inactivation of the tumour suppressor gene p53 cumulatively enhance the gastric mutation frequency in Big Blue transgenic mice.[J].2003,201(4).
- [23]L. Wu,A. J. Levine,D. A. Freedman.Functions of the MDM2 oncoprotein[J].1999,55(1).
- [24]Segel LA.,Oren M.,Maya R.,etc.Generation of oscillations by the p53-Mdm2 feedback loop: A theoretical and experimental study[J].2000,97(21).
- [25]Kobayashi Y,Shimmyo T,Ishikawa Y,etc.Etiologic value of p53 mutation spectra and differences with histology in lung cancers.[J].2008,99(2).