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Correlation between N-acetyltransferase 2 gene polymorphisms and genetic Susceptibility to inflammatory bowel disease
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 8
- DOI:
- 10.3969/j.issn.1009-3079.2008.08.013
- Key Word:
- 乙酰基转移酶;炎症性肠病;基因多态性
Abstract： 目的:探讨温州汉族人群中炎症性肠病(IBD)遗传易感性与N-乙酰基转移酶2(NAT2)基因型多态性的相关性.方法:采用聚合酶链反应-限制性片断长度多态性方法,在119例IBD患者及120例健康对照者中,检测NAT2野生型等位基因(NAT2 4)和3种突变型等位基因(NAT2 5B,6A和7B)的频率.结果:在IBD组中,NAT2 4,NAT2 5B,NAT26A和NAT2 7B等位基因频率分别是55.9%,6.7%,23.5%和13.9%,与正常对照组比较无显著差异.CD组和UC组中各等位基因频率与正常对照组比较无显著差异;将NAT2基因型分为快型、中间型和慢型,分别为35.3%,41.2%和23.5%,与正常对照组比较亦无显著差异;对IBD各组进一步分层,也无显著性差异.结论:NAT2基因型多态性和炎症性肠病遗传易感性无显著性相关.
- [1]欧阳晓春,余小骊,刘振华,等.阿尔茨海默病与细胞色素P450 1A1和N-乙酰基转移酶基因多态性的相关研究[J].2007,(6).
- [2]何路军,刘敬闪,乔芳,等.河北汉族人群NAT2基因多态性分析[J].2004,(5).
- [3]高建平,黄跃东,梁建平,等.福建地区汉族人群N-乙酰基转移酶基因多态性[J].2003,(21).
- [4]洪雁,张本恕.N-乙酰基转移酶基因多态性与帕金森病遗传易患性关系的研究[J].2002,(1).
- [5]郝钢跃,张维东,陈永和,等.NAT2基因多态性与膀胱癌遗传易感性的关系[J].2004,(5).
- [6]中华医学会消化病学分会.对炎症性肠病诊断治疗规范的建议[J].2001,(4).
- [7]Hein D.Molecular genetics and function of NAT1 and NAT2: role in aromatic amine metabolism and carcinogenesis.[J].2002,506/507(0).
- [8]Seow-Choen F,Lee EJ,Zhao B.Relationship between polymorphism of N-acetyltransferase gene and susceptibility to colorectal carcinoma in a Chinese population.[J].1998,8(6).
- [9]Fretland AJ,Leff MA,Doll MA,etc.Functional characterization of human N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms.[J].2001,11(3).
- [10]Kumagai S,Sano H,Ishida H,etc.N-acetyltransferase 2 genotype-related efficacy of sulfasalazine in patients with rheumatoid arthritis.[J].2004,21(2).
- [11]Treadwell EL,Cooper GS,Gilkeson GS,etc.N-acetyl transferase genotypes in relation to risk of developing systemic lupus erythematosus.[J].2004,31(1).
- [12]Bell D. A.,Taylor J. A.,Butler M. A.,etc.SHORT COMMUNICATION: Genotype\/phenotype discordance for human arylamine N -acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-Americans[J].1993.
- [13]卢建丰,曹晓梅,刘志海,等.中国人群N-乙酰转移酶多态性的基因分析.[J].1998,(4).
- [14]Roots I,Cascorbi I,Filiz A,etc.Association between the N-acetylation genetic polymorphism and bronchial asthma.[J].2002,54(6).
- [15]Katsuhiko Okumura,Fusao Komada,Manabu Gobara,etc.N-Acetyltransferase 2 Genotype-Related Sulfapyridine Acetylation and Its Adverse Events[J].2002,25(8).
- [16]Brzosko I,Pawlik A,Ostanek L,etc.Increased genotype frequency of N-acetyltransferase 2 slow acetylation in patients with rheumatoid arthritis.[J].2002,72(3).