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Capecitabine in combination with leucovorin and oxaliplatin as adjuvant chemotherapy in the treatment of advanced gastric cancer
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 6
- DOI:
- 10.3969/j.issn.1009-3079.2008.06.018
- Key Word:
- 进展期胃癌;化疗;卡培他滨;奥沙利铂;甲酰四氢叶酸钙
Abstract： 目的:观察卡培他滨(CAPE)联合甲酰四氢叶酸钙(LV)和奥沙利铂(OXA)化疗方案(CAPE-LV-OXA)治疗进展期胃癌(AGC)的临床疗效和毒副反应.方法:AGC患者28例接受CAPE-LV-OXA方案治疗,po LV 90 mg/d及CAPE 1250 mg/(m2·d),d1-14;OXA85mg/m2,静脉滴注2h,d1;每3wk为1个疗程.2-6个疗程后观察疗效及其不良反应.结果:可评价疗效25例,完全缓解0例,部分缓解13例,稳定7例,进展5例,有效率(RR)为52%(13/25),中位肿瘤进展时间(TTP)为5.4(2-13)mo,中位生存时间(MST)为10.3(3-25)mo.毒副反应主要为胃肠道反应、骨髓抑制、手足综合征和黏膜炎等,多为Ⅰ-Ⅱ度毒性反应,所有Ⅲ度毒副反应4例,对症治疗或停止治疗后可缓解.无化疗相关死亡者.结论:CAPE-LV-OXA方案在AGC的治疗中疗效较为肯定,且耐受性良好.
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