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Effect of erythromycin and azithromycin on sensation afferent nerve functions of gastrointestinal tract in rats
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 6
- DOI:
- 10.3969/j.issn.1009-3079.2008.06.007
- Key Word:
- 红霉素;阿齐霉素;迷走神经;胃肠感觉
Abstract： 目的:用电生理方法研究红霉素和阿齐霉素对胃肠感觉传入的影响.方法:64只SD成年大鼠随机分成8组(n=8):红霉素组:对照、小剂量(0.1 mg/kg)、中剂量(0.5 mg/kg)、大剂量(1 mg/kg)组.阿齐霉素组:分组和剂量均与红霉素相同.经颈静脉注射生理盐水、红霉素、阿齐霉素,观察记录注药前和注药后30 min内膈下迷走神经传入自发放电和扩胃诱发放电两种状态下的变化.结果:静脉注射小剂量红霉素和阿齐霉素自发放电和对扩胃诱发放电均无显著变化,20min后中、大剂量红霉素和阿齐霉素注药后自发放电(红霉素:8.34±0.37,8.54±0.26 vs 7.78±0.23,7.84±8.27;阿齐霉素:8.57±0.43,8.28±0.38 vs 7.74±0.21,7.86±0.30)和对扩胃诱发放电均增强(红霉素:8.54±0.34,8.61±0.20 vs 8.13±0.36,8.19±0.21;阿齐霉素:8.54±0.30,8.42±0.21 vs 8.24±0.22,8.22±0.19)与相应的对照组和小剂量组间差异有统计学意义.结论:红霉素和阿齐霉素能显著增加胃肠感觉传入.
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