Paper - WANFANG MED ONLINE

You Position: Home > Paper

Relationship between H pylori infection and reflux esophagitis

( views:316, downloads:58 )

Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 2

DOI:: 10.3969/j.issn.1009-3079.2008.02.010

Key Word:: 幽门螺杆菌;反流性食管炎;胃炎

Abstract：目的:研究反流性食管炎(reflux esophagitis,RE)患者幽门螺杆菌(H pylori)感染率,感染程度与定植部位及胃炎的活动度,并对比H pylori阳性与阴性的RE患者食管炎症的严重程度.方法:选取从2007-01/03在我科行胃镜检查证实的RE患者89例,按年龄,性别进行配对的方式随机抽取无反流对照组89例,对比两组H pylori感染率,感染部位,感染程度的差异,并比较RE组中H ylori阳性与阴性患者食管炎症的严重程度.结果:RE组与对照组H pylori感染率无统计学差异(P=0.137),但RE组H pylori感染程度较对照组轻(P胃体=0.024,P胃窦=0.000),且RE组胃体炎症严重程度较对照组轻(P=0.001);H pylori阳性与阴性的RE患者发生洛杉矶(LA)C级分别占8.3%和1 8.5%,D级分别占4.2%和12.3%,但食管炎症的轻重程度无显著性差异(P=0.353).结论:H pylori的感染程度及胃体胃炎的活动性与RE的形成有负相关性.

Reference

[1]薛艳,周丽雅,林三仁,等.高清晰放大内镜诊断非糜烂性反流病的研究[J].2006,(5).
[2]周丽雅,沈祖尧,林三仁,等.根除幽门螺杆菌对胃黏膜炎症变化的人群随访研究[J].2003,(3).
[3]高炳霞,段丽萍,王琨,等.幽门螺杆菌感染及胃炎类型与反流性食管炎关系的研究[J].2006,(38).
[4]周丽雅,薛艳,林三仁,等.北京地区25年来消化性溃疡及胃癌发病情况的演变[J].2005,(6).
[5]中华医学会消化病学分会.全国慢性胃炎研讨会共识意见[J].2000,(3).
[6]中国胃食管反流病研究协作组.反流性疾病问卷在胃食管反流病诊断中的价值[J].2003,(11).
[7]Jun Zhang,Xiao-Li Chen,Kang-Min Wang,etc.Relationship of gastric Helicobacter pyloriinfection to Barrett's esophagus and gastro-esophageal reflux disease in Chinese[J].2004,(5).
[8]Justin C.Y Wu,Joseph J.Y Sung,Enders K.W Ng,etc.Prevalence and distribution of Helicobacter pylori in gastroesophageal reflux disease: a study from the East[J].1999,94(7).
[9]Ho KY,Wong BC,Cheung TK.Gastroesophageal reflux disease in Asian countries: disorder of nature or nurture?[J].2006,21(9).
[10]Goh KL.Changing trends in gastrointestinal disease in the Asia-Pacific region.[J].2007,8(4).
[11]Spiros Ladas,Theodore Rokkas,Ilkay Simsek.Helicobacter pylori and Non-malignant Diseases[J].2007,12(Suppl.1).
[12]J C YWu,F K LChan,J Y LChing,etc.Effect ofHelicobacter pylorieradication on treatment of gastro-oesophageal reflux disease: a double blind, placebo controlled, randomised trial[J].2004,53(2).
[13]Kato K,Mitsufuji S,Tanaka I,etc.Effect of Helicobacter pylori eradication on gastroesophageal function.[J].2004,19(3).
[14]Armstrong D.Gastroesophageal reflux disease.[J].2005,5(6).
[15]K, Fujimoto.Review article: prevalence and epidemiology of gastro-oesophageal reflux disease in Japan.[J].2004,20 Suppl 8.
[16]Manes, G.,Mosca, S.,Laccetti, M.,etc.Helicobacter pylori Infection, Pattern of Gastritis, and Symptoms in Erosive and Nonerosive Gastroesophageal Reflux Disease.[J].1999,34(7).
[17]Kenneth R, DeVault,Donald O, Castell.Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease.[J].2005,100(1).
[18]Peter Malfertheiner,Steven F. Moss.Helicobacter and Gastric Malignancies[J].2007,12(Suppl.1).
[19]Unal S,Karakan T,Dogan I,etc.The influence of Helicobacter pylori infection on the prevalence of endoscopic erosive esophagitis[J].2006,11(6).
[20]Kenneth R DeVault,Donald O Castell.Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease[J].1999,94(6).
[21]N, Vakil,S V, van Zanten,P, Kahrilas,etc.[The Montreal definition and classification of gastroesophageal reflux disease: a global, evidence-based consensus paper].[J].2007,45(11).