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Technology of metabonomics and its application in gastrointestinal cancer

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 1

DOI:: 10.3969/j.issn.1009-3079.2008.01.013

Key Word:: 代谢组学;核磁共振;质谱;毛细管电泳;消化道恶性肿瘤;早期诊断

Abstract：代谢组学作为系统生物学的一个分支近年发展迅速. 核磁共振技术、各种色谱质谱技术以及毛细管电泳技术的发展和联用, 使得代谢组学在肿瘤学方面有着越来越深入的研究. 消化道恶性肿瘤作为人类最常见的一类肿瘤, 由于患者早期并无特异性症状, 临床发现时多已为进展期, 化疗毒性反应严重, 病死率高. 当前代谢组学作为肿瘤学的研究方法之一, 能从代谢的角度整体分析疾病, 在消化道恶性肿瘤的早期诊断等方面的研究已初显优势. 本文主要介绍代谢组学各类技术方法及其在消化道恶性肿瘤中的应用, 并对其今后的发展趋势作出展望.

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