You Position: Home > Paper
Association analysis of T174M variants of the angiotensinogen gene with hepatocirrhosis
( views:200, downloads:6 )
- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 35
- DOI:
- 10.3969/j.issn.1009-3079.2007.35.017
- Key Word:
- 血管紧张素原;遗传多态性;肝硬化;聚合酶链式反应
Abstract： 目的:研究血管紧张素原(angiotensinogen,AGT)基因T174M分子变异与肝硬化的关系.方法:提取正常人64例和肝硬化患者65例白细胞基因组DNA,通过PCR、限制性片段长度多态性和测序等技术,观察AGT基因型在肝硬化组和正常组分布的差异.结果:AGT基因T174M位点MT和TT基因型的频率在正常组和肝硬化组分别为82.8%、17.2%和84.6%、15.4%,两组之间不存在差异(x2=0.077,P＞0.05).结论:血管紧张素原基因T174M变异与肝硬化没有显著关系.
- [1]Dixon JB,Dixon AF,Powell EE,etc.Pro-fibrotic polymorphisms predictive of advanced liver fibrosis in the severely obese.[J].2003,39(6).
- [2]Yutaka, Takashima,Akatsuki, Kokaze,Naomi, Matsunaga,etc.Relations of blood pressure to angiotensinogen gene T174M polymorphism and alcohol intake.[J].2003,22(4).
- [3]Inoue I,Nakajima T,Williams C S,etc.A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro.[J].1997.
- [4]Ryoichiro Kageyama,Hiroaki Ohkubo,Shigetada Nakanishi.Induction of rat liver angiotensinogen mRNA following acute inflammation[J].1985,129(3).
- [5]P, Corvol,X, Jeunemaitre.Molecular genetics of human hypertension: role of angiotensinogen.[J].1997,18.
- [6]Veisi P,Rashtchizadeh N,Argani H,etc.Renin-angiotensin system polymorphisms and hemoglobin level in renal allografts: a comparative study between losartan and enalapril.[J].2007,39(4).
- [7]Xiao F,Wei H,Song C,etc.Polymorphisms in the promoter region of the angiotensinogen gene are associated with liver cirrhosis in patients with chronic hepatitis B.[J].2006,21(9).
- [8]Gross CM,Perrot A,Geier C,etc.Recurrent in-stent restenosis is not associated with the angiotensin-converting enzyme D/I, angiotensinogen Thr174Met and Met235Thr, and the angiotensin-II receptor 1 A1166C polymorphism.[J].2007,19(6).
- [9]Lin G,Jiang X,Sheng HH,etc.Effect of renin-angiotensin-aldosterone system gene polymorphisms on blood pressure response to antihypertensive treatment.[J].2007,120(9).
- [10]Spence E,Thorburn D,Smith CA,etc.Polymorphisms of the renin-angiotensin system and the severity of fibrosis in chronic hepatitis C virus infection.[J].2005,12(5).
- [11]D A, Chistiakov,R I, Turakulov,V S, Moiseev,etc.[Polymorphism of angiotensinogen T174M gene and cardiovascular diseases in the Moscow population].[J].1999,35.