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New member of the IκB kinases: IKKε
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 33
- DOI:
- 10.3969/j.issn.1009-3079.2007.33.013
- Key Word:
- IKKε;caspase;凋亡
Abstract： IκB激酶家族(IκB kinases,IKKs)是NF-κB信号途径最为重要的成员之一,已发现其在先天性免疫以及炎症反应的调节中发挥关键作用.除IKKα/β/γ之外,作为IKKs的最新成员,IKKε不仅具有与IKKα/β/γ类似的作用,而且最近的研究数据证实IKKε还能通过凋亡蛋白抑制物(inhibitor of apoptosis proteins,IAPs)调节caspases的活性,参加caspases的凋亡和非凋亡依赖性信号途径.
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