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Relationship between Helicobacter pylori infection and associated gastric diseases in Liaoning Province of China
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 33
- DOI:
- 10.3969/j.issn.1009-3079.2007.33.002
- Key Word:
- 幽门螺杆菌;相关性胃疾病;萎缩性胃炎;聚合酶链反应
Abstract： 目的:探讨中国辽宁地区人群H pylori致病基因的疾病相关性,为揭示H pylori的致病机制及监测H pylori相关性胃疾病的高危人群提供线索.方法:选取胃黏膜活检标本491例,分组浅表性胃炎(GS)、萎缩性胃炎(GA)、溃疡(GU)、胃癌(GC),在微需氧的条件下,培养出H pylori222例,并用标准的酚-氯仿方法提取菌种DNA后经聚合酶链反应及琼脂糖凝胶电泳对cagA,vacA,iceA基因亚型进行检测.同时取胃窦、体、角黏膜各1块,经石蜡切片,HE染色,行组织病理学诊断.结果:GA组感染m2(43.1%)亚型菌株构成比最高,与GU(18.2%)和GC(17.9%)组相比差异有统计学意义(P=0.015,P=0.020),与GS(30.00%)组相比差异没有统计学意义(P=0.084).在GA组中,感染slm2亚型菌株有22例(44.9%),与本组病例中其他基因亚型相比差别均有统计学意义,与GU、GC组感染slm2亚型菌株相比差别有统计学意义(P=0.039),与GS组相比差别没有统计学意义(P=0.067).结论:中国辽宁地区人群感染slm2型菌株与萎缩性胃炎发生有关.
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