You Position: Home > Paper
Expression of SOCS1 and STAT3 in hepatocellular carcinoma tissues and its significance
( views:288, downloads:0 )
- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 31
- DOI:
- 10.3969/j.issn.1009-3079.2007.31.012
- Key Word:
- 肝细胞癌;细胞因子信号转导抑制因子1;信号转导子与转录激活子家族3;免疫组化
Abstract： 目的:探讨SOCS1和STAT3蛋白在HCC组织中的表达、相互关系及在HCC发生发展中的意义.方法:应用免疫组化方法检测48例HCC组织和癌周肝组织、肝硬化(liver cirrhosis,LC)组织(n=11)及正常肝组织中(n=11)SOCS1和STAT3的表达水平.结果:癌周肝组织中SOCS1蛋白表达强度显著高于HCC组织,SOCS1蛋白在LC组织及正常肝组织中全部呈阴性表达.HCC组织和癌周肝组织STAT3蛋白阳性表达率显著高于LC组织和正常肝组织;SOCS1在瘤体大小间的表达有显著性差异(P＜0.01).STAT3在表达AFP阴性和阳性癌组织组间有显著性差异(P＜0.05).HCC组织中SOCS1和STAT3表达具有显著等级正相关(rs=0.431,P＜0.01).结论:SOCS1和STAT3表达与HCC的发生密切相关,且两者之间的表达强度具有显著等级正相关.
- [1]Hu XQ,Zhu TF,Zhu SN,etc.Roles of EGFR-Stat3 signal pathway in carcinogenesis of experimental hepatoma in rats.[J].2007,133(3).
- [2]T A, Endo,M, Masuhara,M, Yokouchi,etc.A new protein containing an SH2 domain that inhibits JAK kinases.[J].1997,387(6636).
- [3]Manning JE,Groopman JD,Jackson P,etc.SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity.[J].2001,28(1).
- [4]Giordanetto F,Kroemer RT.A three-dimensional model of Suppressor Of Cytokine Signalling 1 (SOCS-1).[J].2003,16(2).
- [5]T, Naka,M, Narazaki,M, Hirata,etc.Structure and function of a new STAT-induced STAT inhibitor.[J].1997,387(6636).
- [6]Yandava CN,Pillari A,Drazen JM.Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively.[J].1999,61(1).
- [7]R, Starr,T A, Willson,E M, Viney,etc.A family of cytokine-inducible inhibitors of signalling.[J].1997,387(6636).
- [8]Pan Jingbo,Feitelson MarkA,Satiroglu Tufan NLale,etc.Genetic mechanisms of hepatocarcinogenesis.[J].2002,21(16).
- [9]Benicke M,Sommerer F,Tannapfel A,etc.Identification of novel proteins associated with hepatocellular carcinomas using protein microarrays.[J].2003,201(2).
- [10]Liu R,Jin X,Lin HJ,etc.Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells.[J].2001,20(55).
- [11]Crisostomo PR,Morrell ED,Terrell AM,etc.Jak/STAT/SOCS signaling circuits and associated cytokine-mediated inflammation and hypertrophy in the heart.[J].2006,26(3).
- [12]Mai JC,Leong PL,Xi S,etc.Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth.[J].2003,100(7).