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Significance of the serum level of transforming growth factor β1 and its difference in patients with chronic hepatitis B and HBV-induced hepatic cirrhosis
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 29
- DOI:
- 10.3969/j.issn.1009-3079.2007.29.009
- Key Word:
- 转化生长因子β1;乙型病毒性肝炎;纤维化;炎症;酶联免疫吸附
Abstract： 目的:观察血清转化生长因子β1(TGFβ1)水平是否与肝脏炎症、纤维化程度相关及其在慢性乙型肝炎与乙肝肝硬化患者中的差异.方法:慢性乙肝(慢性肝炎组)65例,乙肝肝硬化(肝硬化组)56例,体检健康、乙肝标志物阴性者(正常对照组)50例,均空腹采血,肝纤维化指标(HA、CⅣ、PCⅢ、LN)采用放免法测定,血清TGFβ1检测采用ELISA.结果:慢性肝炎组血清TGFβ1水平明显高于肝硬化组和正常对照组(22±13μg/L vs10±9μg/L,11±9μg/L,P＜0.01),肝硬化组血清TGFβ1水平与正常对照组相比无显著性差异(P＞0.05).肝硬化组PCⅢ与血清TGFβ1水平相关(r=0.269,P=0.045),慢性肝炎和肝硬化组血清TGFβ1水平与肝功能、肝纤维化指标无明显相关性(P＞0.05).结论:血清TGFβ1水平可协助诊断肝脏炎症程度与纤维化程度,但不能作为他们的判断标准.
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