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Retrospective clinical analysis of 109 cases of drug-induced liver disease
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 28
- DOI:
- 10.3969/j.issn.1009-3079.2007.28.017
- Key Word:
- 药物;肝病;药物性肝病
Abstract： 目的:分析总结近年来药物性肝病的情况,提高本病的诊断治疗水平.方法:回顾调查1999-2004年各种药物致药物性肝病109例,分析统计每年药物性肝病发病例数的变迁及临床情况.结果:抗生素、非甾体抗炎药、治疗甲亢药、中草药、抗结核药是主要的损肝药物.急性药物性肝损伤是逐年增加的.肝损伤发生时间因所用药物不同而差异很大,无临床症状者占22.94%,有症状者占77.06%.慢性药物性肝病7例,急性药物性肝损伤102例(肝细胞损伤型67例,胆汁淤积型23例,混合型12例);治愈17例,好转81例,未愈10例,死亡1例.结论:药物性肝病多数表现为急性药物性肝损伤,少数为慢性肝损伤,取决于药物的种类、剂量和给药途径.药物性肝病的早期诊断与重视程度和认识有关,加强规范合理用药及用药监测可以预防本病.
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