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Visceral sensitivity and expression of 5-hydroxytryptamine and c-fos in the spinal dorsal horn in a rat model with irritable bowel syndrome

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Author:
No author available
Journal Title:
WORLD CHINESE JOURNAL OF DIGESTOLOGY
Issue:
25
DOI:
10.3969/j.issn.1009-3079.2007.25.011
Key Word:
肠易激综合征;内脏敏感性;5-羟色胺;c-fos

Abstract: 目的:探讨便秘型肠易激综合征(C-IBS)大鼠模型对直肠球囊扩张的内脏敏感性改变和脊髓背角5-羟色胺(5-HT)、c-fos的分布和异常表达.方法:C-IBS大鼠模型组应用冰水ig方法建立(A组,n=10),和正常对照大鼠(B组,n=10).所有大鼠给予直肠内球囊扩张,检测球囊扩张引起腹部收缩反射的最小容量阈值及球囊不同容量扩张时腹部收缩反射的次数.腰骶段脊髓背角5-HT和c-fos表达应用免疫组织化学染色及计算机图像分析系统半定量进行分析.结果:直肠内球囊扩张时,A组引起腹部收缩的最小容量阈值略高于B组,无明显统计学差异(0.59±0.09 vs 0.57±0.13,P>0.05).直肠球囊扩张体积1.0 mL时A组腹部收缩反射次数低于B组(10.3±3.3 vs 18.3±5.5,P<0.05):体积1.5和2.0 mL高容量扩张时两组无明显差异(P>0.05).A组腰骶段脊髓背角5-HT、c-fos阳性神经组织的面积均明显高于B组(5-HT面积:146.5±15.1 vs 109.3±18.5:5-HT OD:45826±2563.2 vs 29358±8965.5:c-foS面积:125.4±23.3 vs 88.7±23.2:c-fos OD:46258±4642vs 33238±4587;均P<0.05).结论:C-IBS大鼠模型存在对直肠球囊扩张的内脏敏感性异常,脊髓背角5-HT、c-fos的异常表达可能参与c-IBS大鼠内脏敏感性异常的调节.

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