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Expression and clinical significance of estrogen receptor β and vascular endothelial growth factor in colorectal carcinoma
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 24
- DOI:
- 10.3969/j.issn.1009-3079.2007.24.017
- Key Word:
- 大肠癌;雌激素受体β;血管内皮生长因子;免疫组化
Abstract： 目的:探讨雌激素受体β(ERβ)、血管内皮生长因子(VEGF)在大肠癌组织中的表达以及与大肠癌分化程度之间的关系.方法:应用免疫组织化学SP法,检测45例大肠癌中ERβ,VEGF的表达,并以10例正常大肠黏膜组织作对照,分析大肠癌组织中ERβ与VEGF的表达与大肠癌的关系.结果:45例大肠癌组织中,ERβ阳性23例(51.11%),VEGF阳性33例(73.33%).ERβ和VEGF的表达与肿瘤的分化程度有关(P=0.024,P=0.005),而与肿瘤的临床分期无关(P=0.289,P=0.173).ERβ阳性组中,VEGF的表达明显低于ERβ阴性组(56.52% vs 90.90%,P＜0.05).结论:ERβ的阳性表达与大肠癌的发生、发展和预后密切相关,可联合VEGF作为有价值的肿瘤标记和预后指标.
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