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Changes in adrenomedullin 2 in rats with hyperlipidemia and hyperlipidemic fatty liver
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 21
- DOI:
- 10.3969/j.issn.1009-3079.2007.21.017
- Key Word:
- 肾上腺髓质素2;高脂血症;高脂血症性脂肪肝;大鼠;放射免疫法
Abstract： 目的:研究高脂血症、高脂血症性脂肪肝大鼠血浆及肝组织ADM2/IMD的变化,探讨ADM2/IMD在高脂血症、高脂血症性脂肪肝病理过程中的意义.方法:雄性SD大鼠16只,随机均分为对照组与高脂组.大鼠被高脂喂食造模4 wk后,观察大鼠肝脏病理学变化,测定血脂(TG,TC,HDL-C,LDL-C)及肝功能(ALT,AKP);放免法测定血浆及肝组织匀浆ADM2/IMD含量.结果:高脂组体质量、肝质量及肝指数(肝质量/体质量)均显著高于对照组(P＜0.01)肝组织呈轻中度脂肪变.高脂组TG、TC、LDL-C、ALT及AKP均显著高于对照组(0.29±0.05 mmol/L vs 0.18±0.09 mmol/L,2.49±0.35 mmol/L vs 1.25±0.16 mmol/L,1.69±0.18mmol/L vs 0.49±0.06 mmol/L,25.46±5.14 kU/L vs 13.15±2.83kU/L,416.1±42.7U/L vs 281.2±47.3 U/L;P＜0.01).HDL-C则低于对照(0.65±0.11 mmol/L vs 0.75±0.10 mmol/L,P＜0.01).血浆ADM2/IMD水平两组间差异无统计学意义(P＞0.05);但高脂组肝组织匀浆ADM2/IMD水平较对照组高115%(26.21±11.2 pg/mg·pro vs 12.18±2.9 pg/mg·pro,P＜0.01).结论:ADM2/IMD可能与大鼠饮食性高脂血症和高脂血症性脂肪肝病理进程有关.
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