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Review of research and progress related to trefoil factor 1

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 21

DOI:: 10.3969/j.issn.1009-3079.2007.21.001

Key Word:: 三叶因子1;功能;肿瘤

Abstract： TFF1是三叶因子家族成员之一,在胃肠道黏膜屏障和修复中发挥着重要的生理功能.通过与黏蛋白结合对胃肠道起保护作用,并涉及黏膜重建的不同步骤,特别是调节细胞-细胞连接、细胞移行,近年研究发现,TFF1与细胞迁移、增殖、分化、血管形成等密切相关.他可以延迟细胞从G1期向S期转化,从而减少细胞凋亡,参与细胞内蛋白折叠而且与消化道疾病的发生密切相关.TFF1在胃肠道不同的部位发挥的作用不同,在胃组织中发挥肿瘤抑制因子的作用,但在结肠组织中却发挥着致癌因子的作用,促进结肠肿瘤的发生和发展,并且通过不同的信号途径发挥作用.本文主要对上述的新近研究进行综述.

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