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Changes in protein expression and significance of tumor-associated fibroblasts in gastric cancer
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 20
- DOI:
- 10.3969/j.issn.1009-3079.2007.20.017
- Key Word:
- 胃癌;肿瘤相关纤维母细胞;CD34;平滑肌肌动蛋白;转化生长因子β1
Abstract： 目的:探讨胃癌中肿瘤相关纤维母细胞(tumor-associated fibroblasts,TAFs)蛋白表达的改变及与胃癌侵袭转移的关系.方法:应用免疫组织化学方法检测75例胃癌组织及10例正常胃黏膜组织中纤维母细胞CD34,平滑肌肌动蛋白(SMA)和转化生长因子β1(TGF-β1)的表达,分析蛋白表达改变的机制及与胃癌临床病理特征的关系.结果:胃癌组织CD34,SMA和TGF-β1中的阳性表达与正常胃黏膜组织纤维母细胞中的表达(8.0% vs 80.0%,x2=28.220;90.7% vs 30.0%,x2=19.401;89.3% vs 30.0%,x2=17.486;均P＜0.01);SMA和TGF-β1均与与肿瘤浸润深度、临床分期和淋巴结转移有关(均P＜0.05),且两者的表达密切相关(r=0.555,P＜0.05).结论:胃癌细胞可能通过分泌TGF-β1作用于间质,促进CD34(+)纤维母细胞转变为SMA(+)的肌纤维母细胞,从而发挥其促进肿瘤浸润转移的作用.
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