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Hepatitis virus infection and insulin resistance

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 19

DOI:: 10.3969/j.issn.1009-3079.2007.19.001

Key Word:: 乙肝病毒;丙肝病毒;慢性感染;胰岛素抵抗

Abstract：肝炎病毒慢性持续感染主要是由乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)所致, 除了引起肝脏损害外, 还与一些肝外组织的损害密切相关. 近年来, 研究资料显示慢性HCV和HBV感染与糖尿病和脂肪肝等代谢性疾病的发病密切相关, 而胰岛素抵抗(IR)可能是其发病机制的中心环节. IR也是肝纤维化进展的相关因素, 并影响慢性肝炎病毒感染时抗病毒治疗的疗效. 此外, 糖尿病还可能增加肝炎病毒致癌的作用, 应该引起肝病医师的高度重视. 本文就近年来对HCV和HBV感染中IR发生机制方面的研究, IR在HCV和HBV感染相关的糖尿病和脂肪肝中的作用和影响及其对临床的指导意义作一述评.

Reference

[1]李光伟.胰岛素抵抗评估及其临床应用[J].2004,(1).
[2]李莉,成军,李梵,等.慢性丙型病毒性肝炎脂肪变的临床与病理学特点[J].2002,(9).
[3]成军.慢性丙型病毒性肝炎肝脏脂肪变的机制及其意义[J].2002,(9).
[4]Francesco Negro.Mechanisms and significance of liver steatosis in hepatitis C virus infection[J].2006,(42).
[5]李志群,朱思和,陈焕永,等.乙型肝炎患者血清中肿瘤坏死因子α、γ干扰素及白细胞介素-12检测结果[J].2004,(5).
[6]范小玲,徐道振,李,等.北京地区慢性肝炎合并糖尿病临床调查[J].2001,(2).
[7]陆荫英,刘妍,成军,等.HBsAg结合蛋白C-12基因转染肝癌细胞的基因表达谱芯片分析[J].2004,(1).
[8]朱斌,张平,王昕红,等.血清瘦素水平、胰岛素抵抗与慢性丙型肝炎抗病毒应答的相关性[J].2006,(12).
[9]时德仁,东传凌,陆立,等.肝硬化时糖代谢紊乱与肝细胞胰岛素受体及胰腺细胞HBV DNA表达的关系[J].2003,(4).
[10]Pawlotsky JM,Roudot Thoraval F,Zafrani ES,etc.Different mechanisms of steatosis in hepatitis C virus genotypes 1 and 3 infections.[J].2004,11(5).
[11]Imbert-Bismut F,Messous D,Myers RP,etc.Association between leptin, metabolic factors and liver histology in patients with chronic hepatitis C.[J].2007,21(5).
[12]Zeuzem S,Lormann J,Berger A,etc.Evaluation of factors controlling glucose tolerance in patients with HCV infection before and after 4 months therapy with interferon-alpha.[J].2000,30(2).
[13]Galland-Jos C,Hillon P,Verges B,etc.Risk factors for diabetes mellitus and early insulin resistance in chronic hepatitis C.[J].2001,35(2).
[14]Takeda N,Ishimori M,Akai A,etc.Effects of long-term interferon-alpha treatment on glucose tolerance in patients with chronic hepatitis C.[J].1999,31(2).
[15]Atsuhiko Kusakabe,Kunio Yamanouchi,Yoshitaka Fukuzawa,etc.Prevalence of diabetes mellitus in Japanese patients infected chronically with hepatitis C virus[J].2003,38(4).
[16]Konrad T,Vicini P,Zeuzem S,etc.Interferon-alpha improves glucose tolerance in diabetic and non-diabetic patients with HCV-induced liver disease.[J].1999,107(6).
[17]Otsuki M,Narita R,Akiyama T,etc.Insulin resistance and insulin secretion in chronic hepatitis C virus infection.[J].2004,41(1).
[18]Andriulli A,Spirito F,Zechini F,etc.Peginterferon alfa-2b and ribavirin for 12 vs. 24 weeks in HCV genotype 2 or 3.[J].2005,352(25).
[19]Amir Houshang, Mohammad Alizadeh,Farahnaz, Fallahian,Seyed Moayed, Alavian,etc.Insulin resistance in chronic hepatitis B and C.[J].1900,25(6).
[20]Di-Marco V,Ferraro D,Mineo C,etc.The impact of insulin resistance, serum adipocytokines and visceral obesity on steatosis and fibrosis in patients with chronic hepatitis C.[J].2007,25(10).
[21]Bacon BR,Cordes BG,Neuschwander Tetri BA,etc.Concurrence of histologic features of steatohepatitis with other forms of chronic liver disease.[J].2003,16(1).
[22]Ikeda Y,Kumon Y,Nakamura T,etc.Clinical significance of the insulin resistance index as assessed by homeostasis model assessment.[J].2001,48(1).
[23]A L, Mason,J Y, Lau,N, Hoang,etc.Association of diabetes mellitus and chronic hepatitis C virus infection.[J].1999,29.
[24]Kyoji Moriya,Hiroshi Yotsuyanagi,Kazuhiko Koike,etc.Alteration of Intrahepatic Cytokine Expression and AP-1 Activation in Transgenic Mice Expressing Hepatitis C Virus Core Protein[J].2002,304(2).
[25]Bayraktaroglu Z,Araz M,Aktaran S,etc.Increased frequency of HCV but not HBV infection in type 2 diabetic patients in Turkey.[J].2002,56(3).
[26]Simo R,Genesca J,Esteban JI,etc.Sustained virological response correlates with reduction in the incidence of glucose abnormalities in patients with chronic hepatitis C virus infection.[J].2006,29(11).
[27]Shu Chen L,Jian Wu Y,Gui Qiang W.Effects of fatty liver and related factors on the efficacy of combination antiviral therapy in patients with chronic hepatitis C.[J].2006,26(2).
[28]Bjoro K,Bell H,Hellum KB,etc.Effect of combined interferon-alpha induction therapy and ribavirin on chronic hepatitis C virus infection: a randomized multicentre study.[J].2002,37(2).