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Advance of the relationship between esophageal cancer and cyclooxygenase-2
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 15
- DOI:
- 10.3969/j.issn.1009-3079.2007.15.013
- Key Word:
- 食管癌;环氧合酶-2;肿瘤发生;预防;治疗
Abstract： 环氧化酶是花生四烯酸代谢中的一种限速酶,其中的同工酶之一的环氧合酶-2,通过多种途径与诸多肿瘤的发生、发展和预后密切相关.食管癌具有高发病率和死亡率,近年来认为环氧合酶-2通过异型生物质(xenobiotic)代谢,抑制凋亡,参与慢性炎症、免疫抑制,上调血管生成因子的表达,以及促进肿瘤的浸润和转移在其致癌中起重要作用.实验证据表明利用选择性环氧合酶-2抑制剂抑制环氧合酶-2活性可以预防各种组织中肿瘤的形成,包括食管癌.本文就环氧合酶-2对食管癌的致癌作用及选择性环氧合酶-2抑制剂的预防和/或治疗作用作一综述.
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