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Expression of CD44 and integrin β1 in peritoneal lavage fluid and their correlations with the peritoneal metastasis of gastric cancer

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Author:
No author available
Journal Title:
WORLD CHINESE JOURNAL OF DIGESTOLOGY
Issue:
11
DOI:
10.3969/j.issn.1009-3079.2007.11.022
Key Word:
胃肿瘤;腹膜种植性转移;CD44;整合素β1

Abstract´╝Ü 目的:探讨腹腔液中CD44和整合素β1 mRNA表达与胃癌腹膜转移的关系.方法:收集50例胃癌患者的腹腔液标本,用RT-PCR法检测其中CD44和整合素β1 mRNA的表达,同时行腹腔液细胞学(PLC)检查.按病灶浸润深度、浆膜类型、PLC检查结果、腹膜转移情况和TNM分期分组,比较不同组之间CD44和整合素β1 mRNA的表达水平.结果:腹腔液CD44 mRNA表达水平与浆膜类型(F=4.59,P<0.05)、腹膜转移有关(t=2.655,P<0.05),与PLC检查(t=3.126,P<0.01)和TNM分期密切相关(t=3.453,P<0.01);腹膜转移组的整合素β1 mRNA表达明显高于未转移组的水平(t=2.241,P<0.05).结论:腹腔液中CD44和整合素β1 mRNA表达与胃癌腹膜转移相关因素及TNM分期密切相关,检测其水平有助于估计胃癌病程进展和患者预后,对腹膜转移的早期诊断也有一定价值.

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