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Research advances in the imbalance of helper T lymphocyte subpopulations and cytokine network in patients with chronic hepatitis B

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 8

DOI:: 10.3969/j.issn.1009-3079.2007.08.001

Key Word:: 慢性乙型肝炎;乙型肝炎病毒;辅助性T细胞;细胞因子网络;免疫

Abstract：辅助性T细胞(helper T cell,Th细胞)是根据功能分类的一个T细胞亚群,根据所分泌细胞因子的不同,Th细胞可分为Th0、Th1、Th2和Th3 4种亚群,其中研究最多的是Th1和Th2两个亚群.Th1/Th2细胞及其细胞因子网络的调节对维持机体正常的免疫功能至关重要.乙型肝炎病毒(HBV)感染机体后,多种因素影响Th细胞增殖并且调节其亚型比例,细胞因子网络受到破坏,在细胞因子介导下便可造成肝脏等组织和器官的损害,直接或间接地影响到乙型肝炎发病及其转归.

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