Paper - WANFANG MED ONLINE

You Position: Home > Paper

X gene:a novel target for anti-hepatitis B virus infection

( views:162, downloads:0 )

Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 7

DOI:: 10.3969/j.issn.1009-3079.2007.07.009

Key Word:: X基因;乙型肝炎病毒;治疗;靶点

Abstract： X基因是乙型肝炎病毒(hepatitis B virus,HBV)的四个基因之一.最近的研究表明,他不仅参与HBV感染宿主过程,还影响HBV病毒基因的复制和表达,直接或/和间接通过宿主的免疫反应或其他作用,导致HBV致病的系列病理过程,而且在HBV生命周期中具有非常重要的作用.降低或去除X基因转录,或者封闭X蛋白某些功能以及使X基因表达沉默均能显著抑制病毒复制水平.本文通过对X基因在HBV复制和基因表达中的作用以及针对X基因的干预对HBV复制和基因表达的影响的最新研究成果进行综述,提出X基因是乙肝抗病毒治疗的一个新靶点.

Reference

[1]陆荫英,李克,成军,等.乙型肝炎病毒X基因酵母表达载体构建及表达[J].2002,(1).
[2]H S, Chen,S, Kaneko,R, Girones,etc.The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks.[J].1993,67.
[3]Marion PL,Moolla N,Crowther C,etc.Effective inhibition of HBV replication in vivo by anti-HBx short hairpin RNAs.[J].2006,13(2).
[4]Hou W,Ni Q,Wo J,etc.Inhibition of hepatitis B virus X gene expression by 10-23 DNAzymes.[J].2006,72(3).
[5]陶小红,沈鼎明.乙肝病毒X蛋白与肝细胞癌变[J].1997,(2).
[6]Lai, Ching-Lung,Chien, Rong-Nan,Leung, Nancy W.Y.,etc.A One-Year Trial of Lamivudine for Chronic Hepatitis B.[J].1998,339(2).
[7]Feitelson MA,Woo J,Sun B,etc.X region deletion variants of hepatitis B virus in surface antigen-negative infections and non-A, non-B hepatitis.[J].1995,172(3).
[8]Scaglioni PP,Wands JR,Melegari M.Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication.[J].1998,72(3).
[9]S W, Schalm,R A, de Man,R A, Heijtink,etc.New nucleoside analogues for chronic hepatitis B.[J].1995,22.
[10]王小众,陶其敏.乙肝病毒X基因与肝癌[J].1999,(12).
[11]J R, Wands,M, Geissler,J Z, Putlitz,etc.Nucleic acid-based antiviral and gene therapy of chronic hepatitis B infection.[J].1997,12(9-10).
[12]吴亚平.全球性应用乙肝疫苗预防和控制乙型肝炎[J].1989,010 (1).
[13]PATERLINI P.Selective accumulation of the X transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinoma*1[J].1995.
[14]Massimo Levrero,O. Jean-Jean,C. Balsano,etc.Hepatitis B virus (HBV) X gene expression in human cells and anti-HBx antibodies detection in chronic HBV infection[J].1990,174(1).
[15]Kim SI,Park M,Kim M,etc.Efficient inhibition of hepatitis B virus replication by small interfering RNAs targeted to the viral X gene in mice.[J].2006,119(2).
[16]Schneider RJ,Klein NP,Bouchard MJ,etc.Src kinases involved in hepatitis B virus replication.[J].1999,18(18).
[17]W L, Wang,W T, London,L, Lega,etc.HBxAg in the liver from carrier patients with chronic hepatitis and cirrhosis.[J].1991,14.
[18]Tiollais P,Sitterlin D,Transy C,etc.Correct binding of viral X protein to UVDDB-p127 cellular protein is critical for efficient infection by hepatitis B viruses.[J].2000,19(38).
[19]Brown NA,Schiff ER,Rubin M,etc.Lamivudine as initial treatment for chronic hepatitis B in the United States.[J].1999,341(17).
[20]F, Zoulim,J, Saputelli,C, Seeger.Woodchuck hepatitis virus X protein is required for viral infection in vivo.[J].1994,68.
[21]S, Lev,H, Moreno,R, Martinez,etc.Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions.[J].1995,376.
[22]Wang LH.,Puro RJ.,Bouchard MJ.,etc.Activation and inhibition of cellular calcium and tyrosine kinase signaling pathways identify targets of the HBx protein involved in hepatitis B virus replication[J].2003,77(14).
[23]Bouchard MJ,Wang LH,Schneider RJ.Activation of focal adhesion kinase by hepatitis B virus HBx protein: Multiple functions in viral replication[J].2006,80(9).
[24]Otano I,Aldabe R,Gonzalez-Aseguinolaza G,etc.Gene therapy for viral hepatitis.[J].2006,6(12).
[25]Murakami S,Oishi N,Kaneko S,etc.Molecular functions and biological roles of hepatitis B virus x protein.[J].2006,97(10).
[26]F, von Weizs?cker,S, Wieland,J, K?ck,etc.Gene therapy for chronic viral hepatitis: ribozymes, antisense oligonucleotides, and dominant negative mutants.[J].1997,26.