You Position: Home > Paper
Expression of E-cadherin,β-catenin and Cyclin D1 in gastric adenocarcinoma and their clinical significances
( views:238, downloads:24 )
- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 4
- DOI:
- 10.3969/j.issn.1009-3079.2007.04.016
- Key Word:
- 关键词胃癌;免疫组织化学;E-cadherin;β-catenin;Cyclin D1
Abstract： 目的:研究E-cadherin,β-catenin,Cyclin D1在胃腺癌组织中的表达,探讨三者的表达及临床病理意义.方法:采用免疫组织化学SP法检测73例胃腺癌组织及18例正常胃黏膜组织中E-cadherin,β-catenin,Cyclin D1蛋白的表达.结果:正常胃黏膜组织中E-cadherin和β-catenin均呈清晰的棕褐色染色在上皮细胞细胞膜.E-cadherin和β-catenin在胃癌细胞中出现细胞质和/或细胞核异常染色,其异常表达率分别为63.01%(46/73)和56.16%(41/73),且两者的异常表达与胃腺癌的分化程度、TNM分期、浸润深度及淋巴结转移相关,与患者的性别、年龄、肿瘤大小无关.胃腺癌中E-cadherin和β-catenin表达密切相关.Cyclin D1在胃腺癌组织中的阳性表达率为67.12%(49/73),明显高于其在正常胃黏膜组织中的表达(0%,0/18),且与胃腺癌的分化程度和淋巴结转移相关.E-cadherin和β-catenin在胃癌中的异常表达与Cyclin D1的过表达呈显著的正相关(r=0.249,r=0.376,P＜0.05).结论:胃腺癌中存在E-cadherin和β-catenin基因的失活及蛋白表达下调.E-cadherin和β-catenin的异常表达可能通过促使或激活Cyclin D1的过表达而参与胃癌的发生和发展.
- [1]Adam Elzagheid,Annika (A)lgars,Riyad Bendardaf,etc.E-cadherin expression pattern in primary colorectal carcinomas and their metastases reflects disease outcome[J].2006,(27).
- [2]Ze-Yu Wu,Wen-Hua Zhan,Jing-Hua Li,etc.Expression of E-cadherin in gastric carcinoma and its correlation with lymph node micrometastasis[J].2005,(20).
- [3]Setsuo Hirohashi.Inactivation of the E-Cadherin-Mediated Cell Adhesion System in Human Cancers[J].1998,153(2).
- [4]C, Schuhmacher,K F, Becker,U, Reich,etc.Rapid detection of mutated E-cadherin in peritoneal lavage specimens from patients with diffuse-type gastric carcinoma.[J].1999,8.
- [5]Nakamura T,Kobayashi S,Iwase H,etc.Clinical significance of E-cadherin expression in thyroid neoplasms.[J].2001,76(3).
- [6]张晓晖.细胞周期的网络调控系统CYCLINS-CDKS-CKIS及其与肿瘤的关系[J].1997,(2).
- [7]H, Shiozaki,H, Tahara,H, Oka,etc.Expression of immunoreactive E-cadherin adhesion molecules in human cancers.[J].1991,139.
- [8]A Jawhari,S Jordan,S Poole,etc.Abnormal immunoreactivity of the E-cadherin-catenin complex in gastric carcinoma: Relationship with patient survival[J].1997,112(1).
- [9]Kobayashi T,Niimoto S,Goi T,etc.Clinical significance of combined immunohistochemical detection of CD44v and sialyl LeX expression for colorectal cancer patients undergoing curative resection.[J].1998,55(5).
- [10]Arima S,Kotho T,Haraoka S,etc.Relationship between the expression of adhesion molecules in primary esophageal squamous cell carcinoma and metastatic lymph nodes.[J].2003,23(6A).
- [11]K, Nabeshima,T, Inoue,Y, Shimao,etc.Cohort migration of carcinoma cells: differentiated colorectal carcinoma cells move as coherent cell clusters or sheets.[J].1999,14.
- [12]Morin PJ.Beta-Catenin Signaling and Cancer.[J].1999,21(12).
- [13]A U, Jawhari,M J, Farthing,M, Pignatelli.The E-cadherin/epidermal growth factor receptor interaction: a hypothesis of reciprocal and reversible control of intercellular adhesion and cell proliferation.[J].1999,187(2).
- [14]Ilyas M,Tomlinson IP.The interactions of APC, E-cadherin and beta-catenin in tumour development and progression.[J].1997,182(2).
- [15]Seifried A,Le Marchand L,Donlon T,etc.Association of the cyclin D1 A870G polymorphism with advanced colorectal cancer.[J].2003,290(21).
- [16]P, Debruyne,S, Vermeulen,M, Mareel.The role of the E-cadherin/catenin complex in gastrointestinal cancer.[J].1900,62.
- [17]Paul J, Kowalski,Mark A, Rubin,Celina G, Kleer.E-cadherin expression in primary carcinomas of the breast and its distant metastases.[J].2003,5(6).