You Position: Home > Paper
Clinical observation on adverse reaction of combination chemotherapy of lobaplatin,fluorouracil and calcium leucovorin
( views:258, downloads:31 )
- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 1
- DOI:
- 10.3969/j.issn.1009-3079.2007.01.018
- Key Word:
- 毒副作用;联合化疗;洛铂;氟尿嘧啶;四氢叶酸钙
Abstract： 目的:观察和评价洛铂、氟尿嘧啶与四氢叶酸钙联合化疗的毒副作用.方法:应用洛铂、氟尿嘧啶与四氢叶酸钙联合化疗结、直肠癌术后患者26例,共30个疗程,按WHO标准评定毒副反应.结果:毒副作用以骨髓抑制及胃肠道反应为主,其中骨髓抑制以白细胞和血小板减少最为明显.30个疗程中,白细胞减少Ⅰ-Ⅱ级有18次(60.0%),Ⅲ级有2次(6.7%);血小板减少Ⅰ-Ⅱ级为20次(66.7%),Ⅲ级为3次(10.0%).胃肠道反应主要是恶心,占16.7%,发生呕吐者只占3.3%.结论:洛铂、氟尿嘧啶与四氢叶酸钙联合使用是一个较为安全的化疗方案.
- [1]冯光丽,廖美琳,赵家美,等.乐铂单药治疗42例原发性支气管肺癌[J].2000,(4).
- [2]魏嘉,王立峰,刘宝瑞.5-FU相关的药物疗效及毒性预测分子研究进展[J].2005,(15).
- [3]刘福坤,祁晓平,陈彻,等.直肠癌根治术联合放化疗的临床疗效比较[J].2004,(4).
- [4]孙元珏,赵晖,郭跃武,等.草酸铂及羟基喜树碱联合亚叶酸钙和氟尿嘧啶治疗进展期结直肠癌的比较[J].2006,(19).
- [5]姜文奇,林桐榆,徐瑞华,等.乐铂单药治疗乳腺癌的Ⅱ期临床研究[J].1998,(4).
- [6]Gietema JA,Veldhuis G-J,Guchelaar H-J,etc.Phase II and pharmacokinetic study of lobaplatin in patients with relapsed ovarian cancer[J].1995.
- [7]姜文奇,林桐榆,徐瑞华.乐铂单药治疗肺癌的临床研究[J].1998,(4).
- [8]Galanski M,Jakupec MA,Keppler BK.Update of the preclinical situation of anticancer platinum complexes: novel design strategies and innovative analytical approaches.[J].2005,12(18).
- [9]Harstrick Andreas,Bokemeyer Carsten,Scharnofkse Martin,etc.Preclinical activity of a new platinum analogue, lobaplatin, in cisplatin-sensitive and -resistant human testicular, ovarian, and gastric carcinoma cell lines[J].1993.