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Expression of metastasis-associated gene 1 and its correlation with invasion and metastasis of human gastric carcinoma
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 34
- DOI:
- 10.3969/j.issn.1009-3079.2006.34.015
- Key Word:
- 转移相关基因1;基因表达;胃癌;肿瘤转移
Abstract： 目的:探讨MTA1基因在胃癌及癌周组织中的表达及其表达水平与胃癌浸润和转移潜能的相关性.方法:采用荧光定量PCR及Western印迹技术,分别在mRNA和蛋白水平检测42例手术切除的人胃癌组织及癌旁组织中MTA 1的表达,结合胃癌的临床生物学特征分析MTA 1表达与胃癌病理类型、淋巴结转移的关系.结果:胃癌组织中MTA1 mRNA相对量的表达显著高于癌旁胃黏膜组织(0.6711 vs 0.3940,P＜0.01),蛋白水平表达与mRNA一致.低分化胃腺癌组织中的MTA1 mRNA的相对量表达显著高于中高分化胃腺癌组织(0.7475vs 0.3460,P＜0.01),而伴有淋巴结转移的胃癌组织中MTA1 mRNA的相对量表达明显高于不伴有淋巴结转移的胃癌组织(0.8128 vs 0.4933,P＜0.01).结论:MTA1的表达与促进胃癌的转移相关,检测MTA1表达可作为预测胃癌生物学行为、判断胃癌患者预后的一个参考指标.
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