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Advance in EphB2 receptor and its ligand Ephrin-B in colorectal cancer
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 31
- DOI:
- 10.3969/j.issn.1009-3079.2006.31.012
- Key Word:
- 受体酪氨酸激酶EphB2;结直肠癌;肿瘤形成
Abstract： EphB2受体及其配体Ephrin-B系统的功能失调将导致肠上皮具有增殖能力细胞沿着隐窝-鞭毛轴杂乱排列;而且在结直肠癌患者癌组织中,EphB2的表达越低,浸润深度越深,分化越差,远处转移越多,存活率越低;体外实验也证明其高表达在癌细胞菌落形成实验可抑制癌细胞的生长,配体Ephrin-B对EphB2受体的激活可降低肿瘤细胞的侵袭性.在本文中我们将就EphB2/Ephrin-B系统关于肠上皮干细胞迁徙导向的调控,及其在大肠癌的多步癌变过程中的抑制作用的最新研究进展加以综述.
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