You Position: Home > Paper
Expression and significances of interleukin-8 and interleukin-15 in colonic mucosa of colon cancer patients
( views:173, downloads:22 )
- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 28
- DOI:
- 10.3969/j.issn.1009-3079.2006.28.014
- Key Word:
- 结肠癌;白介素-8;白介素-15;免疫组化
Abstract： 目的:研究结肠癌患者结肠黏膜中白介素-8(IL-8)、白介素-15(IL-15)的表达并探讨其临床应用价值.方法:采用免疫组化法检测结肠癌患者结肠黏膜中IL-8,IL-15的表达情况.结果:IL-8染色阳性44例,占66.7%.IL-15染色阳性40例,占60.6%.IL-8和IL-15表达水平与结肠癌临床分期(IL-8:r=0.437,P=0.006;IL-15:r=0.317,P=0.014)、浸润深度(IL-8:r=0.332,P=0.003;IL-15:r=0.312,P=0.015)、淋巴结转移(IL-8:r=0.316,P=0.042;IL-15:r=0.236,P=0.017)、病理分级(IL-8:r=0.826,P=0.0001;IL-15:r=0.368,P=0.001)均呈显著正相关.结论:检测IL-8,IL-15的表达可做为判断结肠癌恶性程度有价值的指标.
- [1]杨春康,陈道达,张惠灏,等.结直肠癌趋化因子IL-8的表达与血管形成的关系[J].2005,(7).
- [2]Hao C.-Y..Alteration of Gene Expression in Macroscopically Normal Colonic Mucosa from Individuals with a Family History of Sporadic Colon Cancer[J].2005.
- [3]Yasui W,Kuniyasu H,Denda A,etc.Interleukin-15 expression is associated with malignant potential in colon cancer cells.[J].2001,69(2).
- [4]Fehniger TA,Cooper MA,Caligiuri MA.Interleukin-2 and interleukin-15: immunotherapy for cancer.[J].2002,13(2).
- [5]T, Ueda,E, Shimada,T, Urakawa.Serum levels of cytokines in patients with colorectal cancer: possible involvement of interleukin-6 and interleukin-8 in hematogenous metastasis.[J].1994,29(4).
- [6]Brew R,Erikson JS,West DC,etc.Interleukin-8 as an autocrine growth factor for human colon carcinoma cells in vitro.[J].2000,12(1).
- [7]Wolff Vorbeck G,Baumgartner U,Baier PK,etc.Cytokine expression in colon carcinoma.[J].2005,25(3B).
- [8]Takenaga K,Ochiai T,Sakiyamna S,etc.Transduction of murine colon carcinoma cells with interleukin-15 gene induces antitumor effects in immunocompetent and immunocompromised hosts.[J].2000,7(2).
- [9]N, Ferrara.Vascular endothelial growth factor and the regulation of angiogenesis.[J].2000,55.
- [10]S, Cao,A B, Troutt,Y M, Rustum.Interleukin 15 protects against toxicity and potentiates antitumor activity of 5-fluorouracil alone and in combination with leucovorin in rats bearing colorectal cancer.[J].1998,58.
- [11]Giorgia, Gri,Claudia, Chiodoni,Elena, Gallo,etc.Antitumor effect of interleukin (IL)-12 in the absence of endogenous IFN-gamma: a role for intrinsic tumor immunogenicity and IL-15.[J].2002,62.
- [12]A, Li,M L, Varney,R K, Singh.Expression of interleukin 8 and its receptors in human colon carcinoma cells with different metastatic potentials.[J].2001,7(10).
- [13]Di Carlo-E,Meazza R,Basso S,etc.Dissimilar anti-tumour reactions induced by tumour cells engineered with the interleukin-2 or interleukin-15 gene in nude mice.[J].2000,191(2).
- [14]Ogasawara N,Higashiyama S,Mori Y,etc.IL-8 promotes cell proliferation and migration through metalloproteinase-cleavage proHB-EGF in human colon carcinoma cells.[J].2005,29(6).
- [15]H, Kuniyasu,N, Oue,H, Shigeishi,etc.Prospective study of Ki-67 labeling index in the mucosa adjacent to cancer as a marker for colorectal cancer metastasis.[J].2001,20.
- [16]A R, Huber,S L, Kunkel,R F, Todd,etc.Regulation of transendothelial neutrophil migration by endogenous interleukin-8.[J].1991,254(5028).