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Experimental study on severe acute pancreatitis-induced intra-abdominal hypertension complicated with acute lung injury
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 26
- DOI:
- 10.3969/j.issn.1009-3079.2006.26.005
- Key Word:
- 重型急性胰腺炎;腹内压;肺损害;模型
Abstract： 目的:探讨大鼠重型急性胰腺炎(SAP)并发腹内压(IAP)增高(IAH)对肺脏的病理损害.方法:健康Wistar大鼠91只,分为假手术组、SAP模型组及SAP+IAH组.在不同时间(1,2,4 h)SAP模型的基础上,给大鼠不同IAP(2,4,10 cmH2O),观察肺脏的功能及组织结构变化.结果:随着腹内压的升高及作用时间的延长,氧分压(PaO2)明显下降、二氧化碳分压(PaCO2)升高,肺组织含水量增加.光镜下可以观察到肺脏间质及肺泡炎性细胞浸润、水肿、出血,肺泡细胞出现空泡化、脱落及衰变等病理改变.电镜下观察到Ⅱ型肺泡上皮细胞核固缩,板层体呈空泡样,线粒体嵴肿胀,形成凋亡细胞等病理改变.结论:SAP并发IAP增高可导致大鼠肺损伤.
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