Expression of P53, P63 and P73 protein and their significances in gastric adenocarcinoma
- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 24
- DOI:
- 10.3969/j.issn.1009-3079.2006.24.010
- Key Word:
- 胃癌;P53,P63,P73蛋白;基因;免疫组化
Abstract： 目的:探讨P53,P63和P73蛋白表达与胃腺癌临床病理特征之间的关系.方法:用免疫组织化学技术,检测72例胃腺癌及其癌旁正常组织中P53,P63和P73蛋白表达情况.所有研究对象均为湖北地区汉族人.其中,癌肿位于胃远端(胃窦、胃角)51例,胃近端(胃底、胃体)21例;肠型GAC 44例、弥漫型28例;高分化腺癌20例、中分化腺癌29例、低分化和未分化腺癌23例;TNM分期:Ⅰ和Ⅱ期13例,Ⅲ和Ⅳ期59例.结果:胃腺癌组织中P53,P63和P73蛋白阳性表达率均明显高于正常组织(χ2=4.72,P＜0.05;χ2=5.51,P＜0.05;χ2=9.75,P＜0.01);胃窦/胃角腺癌与胃底/胃体腺癌组织P53蛋白表达率无显著差异(P＞0.05);在弥漫型胃腺癌中的表达率明显高于肠型胃腺癌(χ2=4.68,P＜0.05);在低分化腺癌与高中分化腺癌之间以及Ⅲ,Ⅳ期腺癌与Ⅰ,Ⅱ期胃腺癌之间的表达率的差异均有显著性(χ2=7.06,P＜0.05;χ2=3.95,P＜0.05).P63蛋白在低分化腺癌组织中表达率明显高于高中分化腺癌(χ2=7.36,P＜0.05);在胃窦/胃角腺癌与胃底/胃体腺癌之间、在弥漫型与肠型胃腺癌之间、在Ⅰ,Ⅱ期胃腺癌与Ⅲ,Ⅳ期腺癌之间均无显著差异.P73蛋白在Ⅰ,Ⅱ期胃腺癌组织中的阳性表达率明显低于Ⅲ,Ⅳ期腺癌(χ2=4.14,P＜0.05),在胃窦/胃角腺癌与胃底/胃体腺癌之间、在弥漫型与肠型胃腺癌之间、在高、中及低分化胃腺癌之间均无显著差异.在P53蛋白阳性与阴性表达的胃腺癌之间,P63和P73蛋白阳性表达率的差异无显著性.结论:P53,P63和P73过度表达与胃腺癌的发生相关联,但并无交互作用.
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