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Experimental study on microwave tissue coagulation of canine pancreas
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 21
- DOI:
- 10.3969/j.issn.1009-3079.2006.21.005
- Key Word:
- 微波固化;胰腺癌;犬胰腺;病理变化
Abstract： 目的:通过对犬胰腺微波固化后的机体生理状态及病理改变的观察,以期探讨微波固化应用于胰腺的可行性与安全性.方法:成年健康杂种犬15条,无菌手术暴露胰腺下叶后,利用微波探头以50 W功率,1 cm为间距固化5点,每点固化时间为3 min.术后监测淀粉酶等血生化指标,并分别于术后即刻、1 d及1 wk各处死5条.利用HE法、NADH组织活性染色及TUNEL染色对固化中心区及固化旁组织进行病理分析.结果:术后即刻血淀粉酶开始升高,术后48-72 h出现峰值,无并发症者均于1 wk内降至正常.术后即刻可见固化区组织呈凝固性坏死,组织活性消失,与周围组织分解明显.1 d后可于固化旁组织发现大量凋亡细胞.1 wk后固化区纤维组织增生包裹.结论:微波固化治疗胰腺疾病是安全可行的.
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