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Clinical significance of micrometastasis in lymph nodes of mucosal gastric cancer
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 20
- DOI:
- 10.3969/j.issn.1009-3079.2006.20.016
- Key Word:
- 胃黏膜内癌;微转移;Cytokeratin;免疫组织化学
Abstract： 目的:研究胃黏膜内癌淋巴结微转移的发生率、病理学特征及其临床意义.方法:胃黏膜内癌患者84例手术切除淋巴结2526枚进行连续超薄切片,分别进行HE染色及抗Cytokeratin(CK;CAM5.2)免疫组化研究,并与临床病理资料进行对比分析.结果:在84例中16例患者具有淋巴结受累(19%);2526枚淋巴结中45枚淋巴结受累(1.8%;45/2526),显著高于HE染色的1.2%(1/84;P＜0.05),淋巴结微转移率为18%(15/84).尽管没有显著统计学差异,微转移在大于1.0 cm的肿瘤(15/72;21%)较小于或等于1.0 cm的肿瘤(1/12;8%)更为多见(P=0.307).大于2.0 cm的肿瘤,淋巴结的微转移均为淋巴结内多发散在或聚集状态的肿瘤细胞.结论:胃黏膜内癌具有较高的淋巴结微转移率,内镜下黏膜切除术不宜用于直径大于1.0 cm的胃黏膜内癌.
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