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Clinical significance of serum hepatitis B virus large surface protein in diagnosis and treatment of patients with hepatitis B
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 16
- DOI:
- 10.3969/j.issn.1009-3079.2006.16.007
- Key Word:
- 乙型肝炎病毒;大蛋白;HBV DNA;乙型肝炎病毒前S1抗原;乙型肝炎病毒前S2抗原;酶联免疫吸附试验;荧光定量聚合酶链反应
Abstract： 目的:探讨乙肝病毒(HBV)大蛋白(LP)在乙型肝炎诊治中的临床意义.方法:对162例HBV感染者及47名正常对照血清采用酶联免疫吸附试验检测HBV-LP,HBV前S1抗原,HBV前S2抗原及乙型肝炎血清标志物;FQ-PCR定量检测HBV DNA.结果:在HBV感染组中,HBV-LP与HBVDNA,HBeAg,HBVpreS2,HBVpreS1间相关显著(x2=9.22,11.89,60.35,99.87;均P＜0.01),其含量与HBV DNA拷贝数成正相关(rs=0.64,P＜0.001),不同HBV DNA拷贝数组别间HBV-LP含量存在差异显著性(x2=135.34,P＜0.01);HBeAg,HBV DNA,HBVpreS2,HBVpreS1不同模式间HBV-LP含量及阳性率均存在差异显著性(Z=8.70,5.85,8.44,8.84,均P＜0.001);HBeAg阴性感染血清中HBV-LP较HBV DNA,HBVpreS2,HBVpreS1更为敏感(76.8%).HBV感染组与正常对照组间HBV-LP含量存在差异显著性(P＜0.01).结论:HBV-LP是从蛋白水平反映HBV感染者体内病毒复制程度的可靠指标,尤其是HBeAg阴性患者体内病毒复制及预后判断的良好血清学监测指标.
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