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Investigation of Ala54Thr polymorphism in intestinal fatty acid binding protein in Han and Mongoloid populations

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 13

DOI:: 10.3969/j.issn.1009-3079.2006.13.014

Key Word:: IFABP基因;单核苷酸多态性;高脂饮食;蒙古族;汉族

Abstract：目的:调查蒙、汉族人群小肠脂肪酸结合蛋白(IFABP)基因exorⅡ54位点编码丙氨酸或苏氨酸(A/T)单核苷酸多态性(SNP),探讨不同种族、饮食习惯与IFABP基因多态性频率分布的关系.方法:采用聚合酶链反应(PCR),DNA限制性内切酶酶切及基因测序等技术,分别对208例牧区蒙古族人群、150例张家口市区蒙古族人群和190例汉族人群54A/TIFABP基因型分析.结果:牧区蒙古人群54T等位基因频率为0.51,54A等位基因频率为0.49;市区蒙古族人群54T等位基因频率为0.33,54A等位基因频率为0.67;汉族人群54T等位基因频率为0.30,54A等位基因频率为0.70.与市区蒙古族人群、汉族人群相比,牧区蒙古族人群突变型54T等位基因频率明显增高,且差别有统计学意义(分别为χ2=22.98,P＜0.01;χ2=34.23,P＜0.01).市区蒙古族和汉族相比较,突变型54T等位基因频率无明显差异(χ2=0.47,P＞0.05).结论:蒙、汉族人群IFABP基因54A/T多态性频率分布无种族差别;牧区蒙古族人群突变型54T IFABP基因高频率分布可能与高脂饮食习惯有关.

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