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Expression and significance of hypoxia-inducible factor-1 alpha in esophageal squamous cancer cell line EC-109

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Author:
No author available
Journal Title:
WORLD CHINESE JOURNAL OF DIGESTOLOGY
Issue:
13
DOI:
10.3969/j.issn.1009-3079.2006.13.002
Key Word:
缺氧;缺氧诱导因子-1α;食管鳞癌;基因表达调控

Abstract: 目的:探讨缺氧诱导因子-1α(HIF-1α)在食管鳞癌细胞系EC-109中的表达及其意义.方法:采用逆转录聚合酶链反应(RT-PCR)和Western blot分别检测HIF-1αmRNA和蛋白在常氧及缺氧状态下在食管鳞癌EC-109细胞中的表达.结果:HIF-1αmRNA在缺氧食管鳞癌EC-109细胞中过表达(P<0.05),在缺氧24 h时HIF-1αmRNA表达最高,其后随时间延长表达下降;HIF-1α蛋白水平在缺氧食管鳞癌EC-109细胞中无明显上调(P>0.05).结论:低氧可诱导食管鳞癌EC-109细胞中HIF-1αmRNA的过度表达,缺氧状态下HIF-1α蛋白水平较常氧时无明显增加.

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