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Correlations of serum hepatitis C virus RNA and alanine ransaminase with liver histopathological changes in patients with chronic hepatitis C
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 9
- DOI:
- 10.3969/j.issn.1009-3079.2006.09.016
- Key Word:
- 丙型肝炎病毒;RNA;丙氨酸氨基转移酶;组织病理学
Abstract： 目的:探讨慢性丙型肝炎患者血清HCV-RNA水平、ALT浓度及肝组织病理改变三者之间的关系.方法:采用荧光定量聚合酶链反应(FQ-PCR)检测132例慢性丙型肝炎患者血清中HCVRNA的水平,用生化自动分析仪检测ALT值,其中30例患者进行了肝脏活检,用HE染色,光学显微镜下观察肝脏病理改变.结果:在132例慢性丙型肝炎患者中有98例HCV RNA水平超过1.0×106拷贝/L,阳性率为74.2%,有99例ALT水平超过正常值,异常率为75.0%.HCV-RNA水平与ALT浓度相关性不显著(r=0.40,P=0.695),与ALT异常率呈明显相关(r=1.00,P＜0.01).肝穿病理结果表明,HCV-RNA水平与肝脏的炎症活动度和纤维化程度均不相关(r=0.50,P=0.667;r=0.20,P=0.80).ALT浓度与肝脏的纤维化程度不相关(r=0.40,P=0.60),而与肝脏的炎症活动度呈明显相关(r=1.00,P＜0.01).结论:慢性丙型肝炎患者血清HCV RNA水平与ALT浓度无关,也不能反映肝组织病理损伤程度;ALT浓度与肝脏的纤维化程度无关,但可在一定程度上反映肝脏的炎症改变.
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