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Expression of Foxp3 mRNA in peripheral blood monocytes of patients with ulcerative colitis

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Author:
No author available
Journal Title:
WORLD CHINESE JOURNAL OF DIGESTOLOGY
Issue:
8
DOI:
10.3969/j.issn.1009-3079.2006.08.014
Key Word:
溃疡性结肠炎;转录因子Foxp3;外周血单个核细胞

Abstract´╝Ü 目的:探讨溃疡性结肠炎(UC)患者外周血单个核细胞中Foxp3 mRNA表达及其与疾病活动性的关系.方法:应用逆转录-聚合酶链反应(RT-PCR)检测42例UC患者(活动期22例、缓解期20例)和30例正常对照组外周血单个核细胞Foxp3mRNA的表达水平.结果:UC患者急性期Foxp3 mRNA水平低于正常人,差异有显著性(1.58±0.31vs3.27±0.40,P<0.05);缓解期Foxp3 mRNA水平与正常人差异无显著性*(P=0.104);PBMC中Foxp3mRNA表达水平与Walmsley评分标准有相关性,且呈负相关.结论:UC患者外周血单个核细胞中Foxp3mRNA表达水平显著低于正常人,其参与了UC的发病过程并与疾病的活动性有关.

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