You Position: Home > Paper
Expression of Foxp3 mRNA in peripheral blood monocytes of patients with ulcerative colitis
( views:239, downloads:13 )
- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 8
- DOI:
- 10.3969/j.issn.1009-3079.2006.08.014
- Key Word:
- 溃疡性结肠炎;转录因子Foxp3;外周血单个核细胞
Abstract： 目的:探讨溃疡性结肠炎(UC)患者外周血单个核细胞中Foxp3 mRNA表达及其与疾病活动性的关系.方法:应用逆转录-聚合酶链反应(RT-PCR)检测42例UC患者(活动期22例、缓解期20例)和30例正常对照组外周血单个核细胞Foxp3mRNA的表达水平.结果:UC患者急性期Foxp3 mRNA水平低于正常人,差异有显著性(1.58±0.31vs3.27±0.40,P＜0.05);缓解期Foxp3 mRNA水平与正常人差异无显著性*(P=0.104);PBMC中Foxp3mRNA表达水平与Walmsley评分标准有相关性,且呈负相关.结论:UC患者外周血单个核细胞中Foxp3mRNA表达水平显著低于正常人,其参与了UC的发病过程并与疾病的活动性有关.
- [1]Jennings CE,Bridges NA,Lachaux A,etc.Mutational analysis of the FOXP3 gene and evidence for genetic heterogeneity in the immunodysregulation, polyendocrinopathy, enteropathy syndrome.[J].2003,88(12).
- [2]Rudensky AY,Fontenot JD.A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3[J].2005,6(4).
- [3]Ramsdell F.Foxp3 and natural regulatory T cells. Key to a cell lineage?[J].2003,19(2).
- [4]Claudio Fiocchi.Inflammatory bowel disease: Etiology and pathogenesis[J].1998,115(1).