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Association between HLADQA1 alleles and H pylori infection in Bai-ethnic children from Kunming
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 4
- DOI:
- 10.3969/j.issn.1009-3079.2006.04.016
- Key Word:
- 白族儿童;幽门螺杆菌;HLA-DQA1
Abstract： 目的:探讨昆明白族儿童HLA-DQA1等位基因位点上是否存在幽门螺杆菌(Hpylori)感染的易感基因或抵抗基因,研究Hpylori感染的免疫遗传机制.方法:应用聚合酶链反应-序列特异性引物(PCR-SSP)方法对应用胶体金标疫渗滤法(DIGFA)和免疫印迹法联合诊断的32例Hpylori感染昆明白族儿童(实验组)和34例无Hpylori感染的昆明白族儿童(对照组)进行HLA-DQA1基因分型检测.结果:实验组HLA-DQA1*010401或*0402基因频率明显低于对照组,两组比较差异存在显著性(0 vs 15%,χ2=0,P=0.001,Pc=0.014,OR=1.172,95%CI:1.062-1.294).结论:HLA-DQA1*010401或*0402基因可能对Hpylori感染具有免疫抵抗作用.
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