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Expression and correlations of S-phase kinase associated protein 2 and P27 protein in pancreatic cancer tissues: an analyses of 51 cases
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 22
- DOI:
- 10.3969/j.issn.1009-3079.2005.22.021
- Key Word:
- 胰腺肿瘤;S期激酶相关蛋白-2;P27蛋白;免疫组织化学
Abstract： 目的:研究胰腺导管癌和慢性胰腺炎组织中(S期激酶相关蛋白-2)SKP2和P27表达,探讨其临床病理意义及两者在胰腺导管癌中表达的相互关系.方法:5l例胰腺导管癌和10例慢性胰腺炎手术切除标本常规制作石蜡包埋切片,SKP2和P27染色方法为SP免疫组化法.结果:51例胰腺导管癌SKP2阳性表达28例(54.9%)和P27阳性表达25例(49.0%),10例慢性胰腺炎SKP2阳性2例(20.0%)和P27阳性9例(90.0%),两者之间均存在显著差异(P＜0.05),高分化腺癌(7/20,35.0%)和未转移(5/16,31.2%)病例SKP2表达阳性率明显低于低分化腺癌(14/19,73.7%)和转移(23/35,65.7%)病例,均存在显著差异(P＜0.05);高分化腺癌(13/20,65.0%)和未转移(12/16,75.0%)病例P27表达阳性率明显高于低分化腺癌(6/19,31.5%)和转移(13/35,37.1%)病例,有显著或高度显著差异(P＜0.05或P＜0.01).SKP2和P27在胰腺导管癌中表达呈密切相关(χ2=14.33,P＜0.01).结论:SKP2和P27表达是反映胰腺导管癌发生,发展及预后的重要生物学标记物,SKP2阳性表达或P27阴性表达者恶性度高、易发生转移及预后不良,且两者表达存在相互调控作用.
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