You Position: Home > Paper
Effect of ulinastatin on nuclear factor-κB expression in acute necrotic pancreatitis in rats
( views:191, downloads:0 )
- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 22
- DOI:
- 10.3969/j.issn.1009-3079.2005.22.016
- Key Word:
- 急性坏死性胰腺炎;乌司他丁;NF-κB;肺损伤;IL-6;TNF-α;血清淀粉酶
Abstract： 目的:探讨乌司他丁对急性坏死性胰腺炎大鼠核因子-κB(NF-κB)的表达及有关细胞因子的影响.方法:将30只Sprague-Dawley大鼠随机分为假手术组(SO组)、急性坏死性胰腺炎组(ANP组)和急性坏死性胰腺炎乌司他丁治疗组(UTI组),比较各组大鼠NF-κB、IL-6、TNF-α、血清淀粉酶的水平.结果:ANP组淀粉酶活性195 907.51±38 61 8.39 nkat/L,TNF-α值41.37±7.54 ng/L,IL-6值32.32±8.62 ng/L,肺、胰腺组织NF-κB表达增加,与SO组比较P均＜0.01,乌司他丁治疗后,淀粉酶活性69 804.30±19 432.55 nkat/L,TNF-α值18.66±6.45 ng/L,IL-6值23.41±7.65 ng/L,肺、胰腺组织NF-κB表达降低,与SO组和ANP组比较P均＜0.01.结论:急性坏死性胰腺炎时NF-κB活化,上调IL-6、TNF-α,加重胰腺及肺的损伤,乌司他丁抑制NF-κB表达而减轻胰腺及肺的损伤,改善急性坏死性胰腺炎的预后.
- [1]秦仁义,王春友,邹声泉.乌司他丁治疗急性胰腺炎的实验及临床研究[J].2001,(4).
- [2]裴红红,杨正安,秦兆寅.核因子κB与急性胰腺炎[J].2001,(4).
- [3]王春友,赵刚,张维康,等.乌司他丁对重症急性胰腺炎的疗效及其作用机制的研究[J].2000,(3).
- [4]U, Siebenlist,G, Franzoso,K, Brown.Structure, regulation and function of NF-kappa B.[J].1994,10.
- [5]K, Yoshida,F, Toki,T, Takeuchi.[Antienzyme preparations in the treatment of acute pancreatitis].[J].1990,48(1).
- [6]James Norman MD.The Role of Cytokines in the Pathogenesis of Acute Pancreatitis[J].1998,175(1).
- [7]Hiroshi Kobayashi,Mika Suzuki,Yoshiko Tanaka,etc.Structure and function analysis of urinary trypsin inhibitor (UTI): identification of binding domains and signaling property of UTI by analysis of truncated proteins[J].2001,1547(1).
- [8]S.Willemer,C.O.Feddersen,W.Karges,etc.Lung injury in acute experimental pancreatitis in rats[J].1991,8(4).
- [9]Vaquero E,Pandol SJ,Gukovsky I,etc.Localized pancreatic NF-kappaB activation and inflammatory response in taurocholate-induced pancreatitis.[J].2001,280(6).
- [10]Gorelick FS,Karne S.Etiopathogenesis of acute pancreatitis.[J].1999,79(4).
- [11]C. W. Imrie,J. C. Ferguson,D. Murphy,etc.Arterial hypoxia in acute pancreatitis[J].1977,64(3).
- [12]M, Brady,S, Christmas,R, Sutton,etc.Cytokines and acute pancreatitis.[J].1999,13(2).
- [13]A U, Steinle,H, Weidenbach,M, Wagner,etc.NF-kappaB/Rel activation in cerulein pancreatitis.[J].1999,116.
- [14]Norman J,Denham W.The potential role of therapeutic cytokine manipulation in acute pancreatitis.[J].1999,79(4).
- [15]C. W. Imrie,A. S. Whyte.A prospective study of acute pancreatitis[J].1975,62(6).
- [16]Dr.IanG.RennerMD, FRACP,WilliamT.SavageIIIMD,JoseL.PantojaMD,etc.Death due to acute pancreatitis[J].1985,30(10).
- [17]Scoazec JY,Roze C,Feldmann G,etc.Differential upregulation of cellular adhesion molecules at the sites of oxidative stress in experimental acute pancreatitis.[J].2001,96(1).
- [18]Pandol SJ,Gukovsky I,Zaninovic V,etc.Early NF-kappaB activation is associated with hormone-induced pancreatitis.[J].1998,275(6 Pt.1).
- [19]M M, Lerch,G, Adler.Experimental animal models of acute pancreatitis.[J].1994,15.
- [20]Mamadi T,Muto Y,Okuhama Y,etc.Protective effects of ulinastatin against ischemia-reperfusion injury.[J].1999,82(1).