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Advance in relationship between trefoil factor and gastric mucosal protection

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 21

DOI:: 10.3969/j.issn.1009-3079.2005.21.012

Key Word:: 三叶因子;胃黏膜保护

Abstract：三叶因子家族是一群主要由胃肠道黏液细胞分泌的小分子多肽.其共同特征为均含一特殊的P结构域及三叶状结构.这种稳定的结构使三叶因子家族具有明显的抗蛋白酶水解、酸消化及耐热特性,因而能在消化道复杂的环境中保持生物活性.目前在哺乳动物体内发现的有pS2/TFF1、SP/TFF2和ITF/TFF3三种,它们具有黏膜保护与修复、肿瘤抑制、信号传导、调节细胞凋亡等功能.本文阐述了三叶因子家族发现的历史,并初步探讨了其作用.同时也对三叶因子受体这一热点的研究现状进行总结.

Reference

[1]卢雅丕,任建林.三叶因子家族研究进展[J].2003,(12).
[2]任建林,卢雅丕,王琳,等.TFF1在正常及损伤胃黏膜中的表达改变[J].2003,(11).
[3]任建林,卢雅丕,陈建民,等.三叶因子1表达与胃黏膜损伤及胃癌的关系[J].2003,(11).
[4]A. Koitabashi,T. Shimada,Y. Fujii,etc.Indometacin up-regulates TFF2 expression in gastric epithelial cells[J].2004,20(s1).
[5]G.A. Cook,M. Familari,L. Thim,etc.The trefoil peptides TFF2 and TFF3 are expressed in rat lymphoid tissues and participate in the immune response[J].1999,456(1).
[6]Ribieras S,Thim L,Rio MC,etc.The trefoil factor 1 participates in gastrointestinal cell differentiation by delaying G1-S phase transition and reducing apoptosis.[J].2002,157(5).
[7]Chadwick MP,Westley BR,May FE.Homodimerization and hetero-oligomerization of the single-domain trefoil protein pNR-2/pS2 through cysteine 58.[J].1997,327(0).
[8]Farrell JamesJ,Wang TimothyC,Koh TheodoreJ,etc.TFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injury.[J].2002,109(2).
[9]S S Poulsen,J Thulesen,E Nex?,etc.Distribution and metabolism of intravenously administered trefoil factor 2/porcine spasmolytic polypeptide in the rat[J].1998,43(2).
[10]Taupin D,Familari M,Giraud AS,etc.Augmented intestinal trefoil factor (TFF3) and loss of pS2 (TFF1) expression precedes metaplastic differentiation of gastric epithelium.[J].2001,81(3).
[11]Giraud AS,Thim L,Levenez F,etc.Secretion of the trefoil factor TFF3 from the isolated vascularly perfused rat colon.[J].2001,101(1).
[12]Xiao-Di Tan,Wei Hsueh,Hong Chang,etc.Characterization of a Putative Receptor for Intestinal Trefoil Factor in Rat Small Intestine: Identification byin SituBinding and Ligand Blotting[J].1997,237(3).
[13]Rowan A,Jawhari A,Bodmer WF,etc.Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells.[J].1998,95(6).
[14]Melissa Verburg,Ingrid B. Renes,Alexandra W.C. Einerhand,etc.Isolation-stress increases small intestinal sensitivity to chemotherapy in rats[J].2003,124(3).
[15]Lynch Devaney K,Thim L,Christensen M,etc.Characterization of human and rat intestinal trefoil factor produced in yeast.[J].1995,34(14).
[16]Westley BR,Feeney J,May FE,etc.Solution Structure of the Disulfide-Linked Dimer of Human Intestinal Trefoil Factor (TFF3): The Intermolecular Orientation and Interactions Are Markedly Different from Those of Other Dimeric Trefoil Proteins.[J].2003,42(51).
[17]W M WONG,R POULSOM,N A WRIGHT.Trefoil peptides[J].1999,44(6).
[18]Westley BR,Gespach C,Mareel M,etc.Selective abrogation of the proinvasive activity of the trefoil peptides pS2 and spasmolytic polypeptide by disruption of the EGF receptor signaling pathways in kidney and colonic cancer cells.[J].2003,22(29).
[19]P.Masiakowski,R.Breathnach,J.Bloch,etc.Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line[J].1982,10(24).
[20]Yu K,Lin J,Lin MF,etc.Extraction and purification of biologically active intestinal trefoil factor from human meconium.[J].2004,84(3).
[21]Shimada T,Koitabashi A,Kuniyoshi T,etc.Up-regulation of TFF expression by PPARgamma ligands in gastric epithelial cells.[J].2003,18(Suppl 1).
[22]Chen W,Babyatsky MW,Lin J,etc.Ontogeny and prenatal expression of trefoil factor 3/ITF in the human intestine.[J].2003,71(2).
[23]Renes IB,Verburg M,Einerhand AW,etc.Epithelial proliferation, cell death, and gene expression in experimental colitis: alterations in carbonic anhydrase I, mucin MUC2, and trefoil factor 3 expression.[J].2002,17(5).
[24]S, Suemori,K, Lynch-Devaney,D K, Podolsky.Identification and characterization of rat intestinal trefoil factor: tissue- and cell-specific member of the trefoil protein family.[J].1991,88.
[25]Chi AL,Lim S,Wang TC.Characterization of a CCAAT-enhancer element of trefoil factor family 2 (TFF2) promoter in MCF-7 cells.[J].2004,25(5).
[26]Jian-LinRen,Jin-YanLuo,Ya-PiLu,etc.Relationship between trefoil factor 1 expression and gastric mucosa injuries and gastric cancer[J].2005,011 (17).
[27]Bouzakri K,Estienne M,Blanchard C,etc.IL-4 and IL-13 up-regulate intestinal trefoil factor expression: requirement for STAT6 and de novo protein synthesis.[J].2004,172(6).
[28]Eliakim R,Fan QX,Babyatsky MW.Chronic nicotine administration differentially alters jejunal and colonic inflammation in interleukin-10 deficient mice.[J].2002,14(6).
[29]Thim L,Mortz E.Isolation and characterization of putative trefoil peptide receptors.[J].2000,90(1).
[30]Raymond J. Playford,Tania Marchbank,Rebecca Chinery,etc.Human spasmolytic polypeptide is a cytoprotective agent that stimulates cell migration[J].1995,108(1).